Cooperation of Antiporter LAT2/CD98hc with Uniporter TAT1 for Renal Reabsorption of Neutral Amino Acids

Conclusions The LAT2/CD98hc and TAT1 transporters functionally cooperate in vivo, and y+LAT1/CD98hc may compensate for the loss of LAT2/CD98hc and TAT1, functioning as a neutral AA exporter at the expense of some urinary loss of cationic AAs. Cooperative and compensatory mechanisms of AA transporters may explain the lack of basolateral neutral aminoacidurias in humans.

Source: Journal of the American Society of Nephrology : JASN - May 31, 2018 Category: Urology & Nephrology Authors: Vilches, C., Boiadjieva-Knöpfel, E., Bodoy, S., Camargo, S., Lopez de Heredia, M., Prat, E., Ormazabal, A., Artuch, R., Zorzano, A., Verrey, F., Nunes, V., Palacin, M. Tags: Basic Research Source Type: research