Pharmacogenetics: Applications to Pediatric Patients.
Pharmacogenetics: Applications to Pediatric Patients.
Adv Pharmacol. 2018;83:191-215
Authors: Adam de Beaumais T, Jacqz-Aigrain E
Abstract
Individual genomic differences may affect drug disposition and effects of many drugs, and identification of biomarkers are crucial to personalize dosage and optimize response. In children, developmental changes associated with growth and maturation translate into different relationships between genotype and phenotype and different responses to treatment compared to adults. This review aims to summarize some developmental aspects of pharmacogenetics, based on practical examples.
PMID: 29801575 [PubMed - in process]
Source: Advances in Pharmacology - Category: Drugs & Pharmacology Authors: Adam de Beaumais T, Jacqz-Aigrain E Tags: Adv Pharmacol Source Type: research