Pharmacogenetics: Applications to Pediatric Patients.

Pharmacogenetics: Applications to Pediatric Patients. Adv Pharmacol. 2018;83:191-215 Authors: Adam de Beaumais T, Jacqz-Aigrain E Abstract Individual genomic differences may affect drug disposition and effects of many drugs, and identification of biomarkers are crucial to personalize dosage and optimize response. In children, developmental changes associated with growth and maturation translate into different relationships between genotype and phenotype and different responses to treatment compared to adults. This review aims to summarize some developmental aspects of pharmacogenetics, based on practical examples. PMID: 29801575 [PubMed - in process]
Source: Advances in Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Adv Pharmacol Source Type: research