Long-Distance Relationships: Suppression of Repeat-Mediated Deletions.

Long-Distance Relationships: Suppression of Repeat-Mediated Deletions.
Trends Genet. 2018 May 24;:
Authors: Morales ME, Kaul T, Deininger P
Abstract
The high proportion of repetitive DNA sequences in the human genome provides tremendous opportunities for DNA rearrangements between non-allelic repetitive elements. The genome must use multiple competing and collaborating repair mechanisms to minimize these types of DNA rearrangements, some of which fail in cancer cells where DNA repair pathways are suppressed.
PMID: 29804746 [PubMed - as supplied by publisher]

Source: Trends in Genetics : TIG - May 24, 2018 Category: Genetics & Stem Cells Authors: Morales ME, Kaul T, Deininger P Tags: Trends Genet Source Type: research