Zanthoamides G-I: Three new alkamides from Zanthoxylum zanthoxyloides

Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Stephanie T. Guetchueng, Lutfun Nahar, Kenneth J. Ritchie, Fyaz M.D. Ismail, Andrew R. Evans, Satyajit D. Sarker Three new alkamides, zanthoamides G-I (1-3), together with ten known compounds, araliopsine, skimmianine, N-methylplatydesminium cation, isoplatydesmine, myrtopsine, atanine, N-methylatanine, sesamin, hesperetin and hesperidin, were isolated from the fruits of Zanthoxylum zanthoxyloides. Their structures were elucidated by spectroscopic means. All isolated compounds were assessed for their cytotoxicity against A549, MCF7, PC3 and PNT2 cell lines. Among the alkamides, only zanthoamide G (1) showed low level of cytotoxicity against MCF7 cells. Graphical abstract

Source: Phytochemistry Letters - May 28, 2018 Category: Chemistry Source Type: research