Influence of peroxisome proliferator-activated receptor- γ exon 2 and exon 6 and insulin receptor substrate (IRS)-1 Gly972Arg polymorphisms on insulin resistance and beta-cell function in Southern Mediterranean women with polycystic ovary syndrome.

Conclusions Our data support the protective influence of PPAR-γ-exon 2 and exon 6 variants on IR and beta cell function, whereas IRS-1 polymorphism is associated with an unfavorable metabolic profile. However, these associations do not fully explain the high metabolic risk associated with PCOS.
Source: Journal of Clinical and Translational Endocrinology - Category: Endocrinology Source Type: research