Prolonged corticosteroid treatment in acute respiratory distress syndrome: impact on mortality and ventilator-free days

Source: Critical Care - Category: Intensive Care Authors: Tags: Letter Source Type: research

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Condition:   Oral Lichen Planus Interventions:   Drug: Oral Zinc supplementation;   Drug: Oral placebo supplementation Sponsor:   Postgraduate Institute of Dental Sciences Rohtak Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsOur study suggests that the CAT can be applied to evaluate the lung ‐specific quality of life in SSc‐ILD similar to IIP regarding the pulmonary function, but it should be noted that pulmonary arterial hypertension in SSc‐ILD influences the CAT score.
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
Condition:   Oral Lichen Planus Interventions:   Drug: Oral Zinc supplementation;   Drug: Oral placebo supplementation Sponsor:   Postgraduate Institute of Dental Sciences Rohtak Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We present a 15-year-old boy with Evans syndrome and common variable immunodeficiency who experienced a severe, refractory flare 16 months postsplenectomy. After failing to respond to multiple other agents, he achieved a durable response to a bortezomib-based regimen. Bortezomib may be a reasonable second or third line option, especially before high-morbidity therapies such as splenectomy or stem cell transplantation.
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research
Many major breakthroughs in biomedical research and therapy development have been possible only because of close cooperation of academic researchers with the pharmaceutical industry. Outstanding historic examples include the discovery of penicillin and its further development, the invention of corticosteroids for therapeutic use, and the identification of streptomycin as a novel antibiotic. Thus, pharmaceutical companies have played crucial roles in the success stories of medicine. Today it is even more important to recognize that the continued development of modern medicine is dependent on technical innovations as well as...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Editorial Source Type: research
Authors: Casals G, Hanzu FA Abstract Determination of cortisol levels in the urine (24 hours urine free cortisol), saliva (late-night), or serum (total cortisol after dexamethasone suppression) is recommended to screen for Cushing's syndrome (CS). This review focuses on the differences between the frequently used cortisol-antibody immunoassay-based methods and the highly specific mass-spectrometry-based methods that are progressively being employed in clinical laboratories for CS screening. The particular characteristics of cortisol metabolism and the lack of specificity of the immunoassays cause marked differences...
Source: Annals of Laboratory Medicine - Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research
CONCLUSIONS: Families who were provided a written asthma action plan during their pediatric emergency department visit for an asthma exacerbation reported fewer unplanned visits during the subsequent three months. PMID: 32066290 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Conclusions There is no high-level evidence to guide tapering until discontinuation after extended courses of medium- to high-dose treatment regimens, as current guidelines rely heavily on expert opinion and small case series with a trial-and-error approach. This review supports the need for additional research to shift tapering recommendations to a more evidence-based practice.
Source: JCR: Journal of Clinical Rheumatology - Category: Rheumatology Tags: Original Articles Source Type: research
Conclusions Inhaled corticosteroid use is not associated with a reduction in lung cancer incidence in patients with COPD. Observational studies reporting such reduction may have been affected by time-related biases and the inclusion of patients with asthma. The proposition of a randomised trial warrants some caution.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: COPD and smoking Original Articles: COPD Source Type: research
Duchenne Muscular Dystrophy (DMD) is an X-linked recessive disease affecting 1 in 4700 male births [1]. A mutation in the dystrophin gene leads to progressive skeletal and cardiac muscle dysfunction [2]. Most patients lose the ability to ambulate between ages 10 and 13 years and subsequently develop progressive cardiac disease in late teenage years [3,4]. Life has been prolonged for patients with DMD with noninvasive ventilatory support [5]. Current standard of care includes corticosteroids, which have been shown to improve strength and pulmonary function [6,7].
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
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