Patient-Derived Xenograft Tumor Models: Overview and Relevance to IR

Preclinical tumor models are the foundation of translational cancer research. For exploring fundamental biologic mechanisms or designing new cancer therapies, in  vitro and in vivo models are the indispensable test environments in which countless discoveries have been made. Conventional models rely on immortalized cell lines that are notable for their reproducibility, convenience, and ease of use. Although these approaches continue to be widely used, their limitations are well known. In particular, these models are often criticized as poor reproductions of clinical tumors.

Source: Journal of Vascular and Interventional Radiology : JVIR - May 22, 2018 Category: Radiology Authors: Rahul A. Sheth, Nicholas Perkons, Eleonora Dondossola, Sumit K. Subudhi, Terence P. Gade, Alda L. Tam Tags: Research in Translation Source Type: research