Pharmacokinetic and Pharmacodynamic Relationship of Blinatumomab in Patients With Non-Hodgkin Lymphoma.

CONCLUSION: B-lymphocyte depletion following blinatumomab infusion was exposure-dependent. Transient cytokine elevation increased with dose; it was less pronounced at low starting dose. Tumor response was a function of exposure, suggesting utility for the PK/PD relationship in dose selection for future studies, including NHL and other malignant settings.
PMID: 29773068 [PubMed - as supplied by publisher]

Source: Current Clinical Pharmacology - May 17, 2018 Category: Drugs & Pharmacology Authors: Hijazi Y, Klinger M, Kratzer A, Wu B, Baeuerle PA, Kufer P, Wolf A, Nagorsen D, Zhu M Tags: Curr Clin Pharmacol Source Type: research