Immunohistochemical expression HIF1 α in chronic plaque psoriasis, an association with angiogenesis and proliferation.

Immunohistochemical expression HIF1α in chronic plaque psoriasis, an association with angiogenesis and proliferation.
J Immunoassay Immunochem. 2018 May 17;:1-14
Authors: Abdou AG, Farag AGA, Hammam M, Taie DM, Abdelaziz RA
Abstract
Psoriasis is characterized by excessive cell proliferation, angiogenesis, and regions of hypoxia. Hypoxia stimulates production of hypoxia inducible factors (HIFs) such as HIF1α. The aim of the present study is to investigate the possible role of HIF1α in pathogenesis of psoriasis and to correlate its expression with angiogenesis and proliferation in involved and uninvolved skin in patients with plaque psoriasis using CD34 and Ki-67. The current study was performed on 40 skin specimens of patients presented with chronic plaque psoriasis both involved and uninvolved together with 40 specimens from age- and sex-matched healthy volunteers as a control group. The specimens were submitted for HIF1α, CD34, and Ki-67 immunostaining. HIF1α was expressed in 37.5% of normal skin with mild intensity and cytoplasmic localization instead of its expression in 72.5% and 100% of uninvolved and involved psoriatic skin, respectively. Nucleocytoplasmic pattern of HIF1α was seen in 34.5% and 37.5% of uninvolved and involved psoriatic skin, respectively. Positive and intense expression of HIF1α as well as its nucleocytoplasmic localization were significantly in favor of psoriatic skin either involved or uninvolved in c...

Source: Journal of Immunoassay and Immunochemistry - May 19, 2018 Category: Biochemistry Tags: J Immunoassay Immunochem Source Type: research