Synthesis of tetronic acids from propargylic alcohols and CO2.

Synthesis of tetronic acids from propargylic alcohols and CO2.
Chem Commun (Camb). 2018 May 17;:
Authors: Shen G, Zhou WJ, Zhang XB, Cao GM, Zhang Z, Ye JH, Liao LL, Li J, Yu DG
Abstract
A direct and practical synthesis of important tetronic acids from easily available propargylic alcohols and carbon dioxide is reported for the first time. This transition-metal-free transformation features high atom- and step-economy, mild reaction conditions, good functional group tolerance and high yield. Preliminary mechanistic studies suggest that the reaction proceeds via cyclization to give alkylidene cyclic carbonate, ring-opening and re-cyclization processes.
PMID: 29770416 [PubMed - as supplied by publisher]

Source: Chemical Communications - May 17, 2018 Category: Chemistry Authors: Shen G, Zhou WJ, Zhang XB, Cao GM, Zhang Z, Ye JH, Liao LL, Li J, Yu DG Tags: Chem Commun (Camb) Source Type: research