Pulmonary Capillary Hemorrhage Induced by Diagnostic Ultrasound in Ventilated Rats

Pulmonary capillary hemorrhage (PCH) can be induced by diagnostic ultrasound —a potential safety issue. Anesthetized rats were intubated for intermittent positive-pressure ventilation (IPPV) with 0 end-expiratory pressure, +4 cm H2O end-expiratory pressure (PEEP) and −4 cm H2O end-expiratory pressure (NEEP). Rats were imaged at 7.6 MHz with a Philips HDI 5000 ultra sound machine. The output was low (mechanical index [MI] = 0.22) for aiming and then was raised for 5 min in 20 different exposure groups with n = 8.
Source: Ultrasound in Medicine and Biology - Category: Radiology Authors: Tags: Original Contribution Source Type: research