SOX11 augments BCR signaling to drive MCL-like tumor development

We report here that overexpression of SOX11 in B cells promotes BCR signaling and a disease phenotype that mimics human MCL.

Source: Blood - May 17, 2018 Category: Hematology Authors: Kuo, P.-Y., Jatiani, S. S., Rahman, A. H., Edwards, D., Jiang, Z., Ahr, K., Perumal, D., Leshchenko, V. V., Brody, J., Shaknovich, R., Ye, B. H., Parekh, S. Tags: Lymphoid Neoplasia Source Type: research