Mesenchymal stromal cells induce a permissive state in the bone marrow that enhances G-CSF-induced hematopoietic stem cell mobilization in mice

Hematopoietic stem cells (HSC) replenish the peripheral blood (PB) cell pool throughout life. During homeostasis, the vast majority of HSC reside in specialized niches, located in the perivascular area of the trabeculated region of the bone marrow (BM). This HSC microenvironment regulates self-renewal, cell cycle entry and differentiation of HSC and consists of a complex network of hematopoietic and non-hematopoietic cells. (reviewed in [1,2]).

Source: Experimental Hematology - May 15, 2018 Category: Hematology Authors: Evert-Jan F.M. de Kruijf, Rob Zuijderduijn, Marjolein C. Stip, Willem E. Fibbe, Melissa van Pel Source Type: research