Chronic sequelae and severe complications of norovirus infection: a systematic review of literature

Worldwide, norovirus has been estimated to cause 18% of all acute gastroenteritis cases [1], ranging from mild to severe (hospitalized).Norovirus infection is generally seen as a mild and self-limiting acute gastroenteritis. However, less well understood are potentially severe or long-term effects after a norovirus infection. Norovirus is found to be associated with mortality in studies using outbreak data, syndromic surveillance, or case-based death certificates [2 –6]. In addition to mortality, norovirus illness has been reported in relation to several severe or life-threatening complications as well as chronic sequelae, such as necrotizing enterocolitis (NEC) [7], benign infantile seizures with gastroenteritis (BICG) [8], or chronic diarrhea [9].
Source: Journal of Clinical Virology - Category: Virology Authors: Tags: Review Source Type: research