Antibiotics Tied to Higher Kidney Stone Risk
The five antibiotic classes newly linked to kidney stone risk included sulfas (Bactrim, Gantanol); cephalosporins (Keflex); fluoroquinolones (Cipro); nitrofurantoin/methenamine (Macrobid, Hiprex); and broad-spectrum penicillins.
To determine social factors associated with advanced stone disease (defined as unilateral stone burden>2cm) at time of presentation to a regional stone referral center. Little is known about social determinants of urolithiasis. We hypothesize that socioeconomic factors impact kidney stone severity at intake to referral centers.
Lower back pain is a common complaint. When back pain occurs on the lower right side, causes can include sprains and strains, kidney stones, infections, and conditions that affect the intestines or reproductive organs. Learn more about what causes back pain on the lower right side and when to see a doctor here.
Abstract PURPOSE: In this retrospective study, we aimed to comparatively evaluate the efficacy and safety of RIRS procedure on an age-based manner in patients younger and above 65 years. MATERIAL AND METHODS: A total of 165 patients undergoing RIRS procedure for renal stones were divided into two groups on an age-based manner namely; Group 1 (n=122) patients aging 65 years) with similar hospitalization as well as stone free rates noted in the younger patients. No procedure related severe complication was noted in these cases. PMID: 31119720 [PubMed - as supplied by publisher]
Condition: Kidney Calculi Interventions: Device: Trilogy Lithotrite; Device: The ShockPulse-SE Lithotripsy System Sponsors: Indiana University; Boston Scientific Corporation; Ohio State University; Mayo Clinic; University of British Columbia Recruiting
Excessive excretion of oxalate in the urine results in the formation of calcium oxalate crystals and subsequent kidney stone formation. Severe forms of hyperoxaluria, including genetic forms and those that result from ethylene glycol poisoning, can result in end-stage renal disease. Therapeutic interventions are limited and often rely on dietary intervention. In this issue of the JCI, Le Dudal and colleagues demonstrate that the lactate dehydrogenase 5 inhibitor (LDH5) stiripentol reduces urinary oxalate excretion. Importantly, stiripentol treatment of a single individual with primary hyperoxaluria reduced the urinary oxal...
Increased urinary oxalate excretion (hyperoxaluria) promotes the formation of calcium oxalate crystals. Monogenic diseases due to hepatic enzyme deficiency result in chronic hyperoxaluria, promoting end-stage renal disease in children and young adults. Ethylene glycol poisoning also results in hyperoxaluria, promoting acute renal failure and frequently death. Stiripentol is an antiepileptic drug used to treat children affected by Dravet syndrome. It has been shown to inhibit neuronal lactate dehydrogenase 5 enzyme. As this isoenzyme is also the last step of hepatic oxalate production, we hypothesized that stiripentol would...
In conclusion, OA could be used as a NOX4 inhibitor to prevent kidney stones.
Asymptomatic, or incidental, pediatric kidney stones detected on abdominal imaging pose a clinical challenge as their significance and expected outcome are not well described. Our primary objective was to estimate the incidence of nephrolithiasis in pediatric patients undergoing abdominal ultrasound (US) or computerized tomography (CT), for all indications, in a pediatric tertiary care hospital. Our secondary objective was to determine the clinical outcome of these radiographically detected stones.