The role of nicotinic receptor genes (CHRN) in the pathways of prenatal tobacco exposure on smoking behavior among young adult light smokers.

CONCLUSIONS: The association between offspring CHRNB3A6 and PTE is a novel finding. The risk of rs16969968 on youth smoking is independent and unrelated to that of PTE among young, light smokers. PTE moderates the protective effect of rs6495308 on youth smoking frequency. However, PTE's pathway to youth smoking behavior was not explained by these genetic factors, leaving its mechanism(s) of action unclear.
PMID: 29751336 [PubMed - as supplied by publisher]

Source: Addictive Behaviors - May 3, 2018 Category: Addiction Authors: Selya AS, Cannon DS, Weiss RB, Wakschlag LS, Rose JS, Dierker L, Hedeker D, Mermelstein RJ Tags: Addict Behav Source Type: research