Real-world effectiveness of 8 weeks treatment with ledipasvir/sofosbuvir in chronic hepatitis C.

We thank Ojha and Steyerberg for making a good point. Indeed, defining analyses populations of real-life observational studies as ITT or PP is problematic as this wording may suggest a higher comparability to clinical trials as is adequate.In principle, even refined methods for adjusting confounders and minimizing bias cannot fully resolve the inherent problem of confounders in such trials. In our paper the wording (ITT and PP) was chosen for comparability with similar previous observational studies (e.g.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research