Japanese cataract patient has respiratory failure from his eye drops
Doctors in Yamanashi - 79 miles (127km) west of the capital Tokyo - believe it is the first recorded case of a such a reaction. They fear he was allergic to levofloxacin - one of the most widely used drops.
Publication date: Available online 13 December 2018Source: Journal of Molecular BiologyAuthor(s): David C. Thorn, Aidan B. Grosas, Peter D. Mabbitt, Nicholas J. Ray, Colin J. Jackson, John A. CarverAbstractThe reducing environment in the eye lens diminishes with age, leading to significant oxidative stress. Oxidation of lens crystallin proteins is the major contributor to their destabilization and deleterious aggregation that scatters visible light, obscures vision and ultimately leads to cataracts. However, the molecular basis for oxidation-induced aggregation is unknown. Using X-ray crystallography and small angle X-ray ...
We present a case of a patient who presented with history of poor vision since the time of cataract surgery 33 months prior, who had cystoid macular edema, reduced endothelial cell count, and apparent Maxitrol ointment (neomycin, polymyxin B sulfate, and dexamethasone in paraffin vehicle; Novartis Pharmaceuticals UK) floating in the AC. The patient was treated with AC washout and sub-Tenon injection of triamcinolone. His vision, retinal architecture by optical coherence tomography, endothelial cell count, and pachymetry has been followed for 9 months following this treatment.Case Rep Ophthalmol 2018;9:493 –498
To evaluate the binocular visual function and depth of focus after staged implantation of diffractive multifocal intraocular lenses (MIOLs) with three different add powers following cataract removal.
CONCLUSIONS: There is a risk of cataract in smokers, particularly nuclear type. With cross-sectional studies, similar results are obtained with cohorts and cases and controls. PMID: 30528895 [PubMed - as supplied by publisher]
Structure of native lens connexin 46/50 intercellular channels by cryo-EM, Published online: 12 December 2018; doi:10.1038/s41586-018-0786-7Cryo-electron microscopy structures of connexin channels composed of connexin 46 and connexin 50 in an open-state reveal features that govern permselectivity and the location of mutated residues linked to herediatry cataracts.
Abstract AIM:: To evaluate the effectiveness of brinzolamide-brimonidine fixed combination to control the intraocular pressure elevation throughout the first 24 h following uncomplicated phacoemulsification cataract surgery. PATIENTS AND METHODS:: A total of 62 patients who underwent phacoemulsification cataract surgery were included in this prospective randomized comparative case series. The brinzolamide-brimonidine fixed combination group (34 eyes) was administered a single dose of brinzolamide-brimonidine fixed combination immediately after phacoemulsification. No treatment was administered in the c...
We read with interest the recent excellent article by Dave and associates describing clinical features and outcomes of eyes with Nocardia endophthalmitis.1 The authors noted that, similar to another large series from India, the majority of cases occurred soon after cataract extraction in immunocompetent patients who presented with extensive anterior chamber inflammation. These postoperative virulent presentations are to be contrasted with the indolent cases we and other groups have previously described associated with endogenous spread and choroidal abscesses in immunocompromised patients.
CONCLUSION: In this analysis, the use of iPCSK9 was not associated with an increased risk of cataracts. PMID: 30502968 [PubMed - as supplied by publisher]
We report the first clinical data demonstrating significantly lower cataract formation rate in retinoblastoma patients treated with lens-sparing radiotherapy in the modern era. Through dose-response modeling, we validate a mean lens dose threshold of 7 Gy to keep the cataract risk under 25%. Although radiotherapy is used significantly less often for Rb due to advances in chemotherapy delivery options, these findings are relevant for refining lens dose constraints.
To evaluate the vision related quality of life (QOL) after implantation of a new trifocal intraocular lens (IOL), using the visual functioning index 14 (VF-14) QOL questionnaire.