Endothelin A (ETA) receptors expressed in renal blood vessels (small and intermediate arteries) of renal transplant patients are connected with acute tubular necrosis (ATN) or antibody mediated rejection (AMR)

The role of non-HLA named anti-ETAR antibodies is discussed as potentially significant but their role is not established. The significance of the ETA receptor and its expression in renal biopsy has not been described yet.We decided to evaluate the presence and relevance of the ETA receptors in renal transplant biopsy for cause.The aim of our study was to evaluate the immunoreactivity of ETA receptor and its significance in patients who had a renal transplant biopsy due to deterioration of transplant function (biopsy for cause) with detailed characterization of staining in small and intermediate arteries of renal transplant biopsies.

Source: Transplantation Proceedings - May 10, 2018 Category: Transplant Surgery Authors: Katarzyna Nowa ńska, Piotr Donizy, Katarzyna Kościelska-Kasprzak, Dorota Kamińska, Magdalena Krajewska, Oktawia Mazanowska, Katarzyna Madziarska, Sławomir Zmonarski, Paweł Chudoba, Bartosz Małkiewicz, Agnieszka Hałoń, Marian Klinger, Mirosław Ban Source Type: research