Breast cancer survivors have increased risk of diabetes

A study, published in theJournal of Clinical Oncology, reports that women successfully treated with hormone therapy for breast cancer have a greater risk of developing diabetes. Medpage Today
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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In this study, we found that senescent chondrocytes isolated from OA patients secrete more EVs compared with nonsenescent chondrocytes. These EVs inhibit cartilage ECM deposition by healthy chondrocytes and can induce a senescent state in nearby cells. We profiled the miR and protein content of EVs isolated from the synovial fluid of OA joints from mice with SnCs. After treatment with a molecule to remove SnCs, termed a senolytic, the composition of EV-associated miR and protein was markedly altered. The senolytic reduced OA development and enhanced chondrogenesis, and these were attributable to several specific differenti...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Discussion: Our results demonstrated that cancer risk was not increased in our MS population; but age and sex different distribution may partly drive cancer risk. Higher cancer risk in MS patients switching more than two DMTs should take into account in treatment decision making. Introduction Multiple Sclerosis (MS) is a severe acquired autoimmune neurodegenerative disease of the central nervous system (CNS) with extremely variable disease course, that usually affects persons in their third/four decades of life, even if late onset is described (1). Women had a prevalence/incidence rate approximately double than men (...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findin...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
In this study, we aimed to estimate the frequency of premalignant and malignant lesions in endometrial polyps, and to evaluate associated clinical and demographic factors. A literature search was performed in major databases and the gray literature using the terms polyps OR endometrial polyp AND endometrial neoplasms OR endometrial cancer OR endometrial hyperplasia OR malignan*. Studies describing the frequency of premalignant and malignant lesions in endometrial polyps and any clinical or demographic factors associated with malignant lesions extracted using hysteroscopy were considered eligible. Independent investigators ...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
The objective of our study was to estimate the frequency of pre-malignant and malignant lesions in endometrial polyps and to evaluate associated clinical and demographic factors. A literature search was performed in major databases and the gray literature using the terms polyps OR endometrial polyp AND endometrial neoplasms OR endometrial cancer OR endometrial hyperplasia OR malignan*. Studies describing the frequency of pre-malignant and malignant lesions in endometrial polyps and any clinical or demographic factors associated with malignant lesions extracted using hysteroscopy were considered eligible. Independent invest...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionsVMS following breast cancer diagnosis was related to a number of modifiable factors, but was unrelated to metabolic syndrome.Implications for Cancer SurvivorsIdentification of factors that predispose women to VMS following a breast cancer diagnosis may allow clinicians to recognize and address VMS in the subset of women who are most likely to experience such symptoms.
Source: Journal of Cancer Survivorship - Category: Cancer & Oncology Source Type: research
ConclusionsAnxiety present in the year prior to breast cancer diagnosis increases the risk of incident CVD in 1-year breast cancer survivors, after adjustment for depression, traditional cardiovascular risk factors, and clinical characteristics.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Conclusions: We found suggestive evidence of an association between ambient air pollution and incidence of postmenopausal breast cancer in European women. https://doi.org/10.1289/EHP1742 Received: 9 February 2017 Revised: 4 August 2017 Accepted: 12 August 2017 Published: 13 October 2017 Address correspondence to Z.J. Andersen, Centre for Epidemiology and Screening, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, 1014 København K, Denmark; Telephone: 45 20740462; Email: zorana.andersen@sund.ku.dk Supplemental Material is available online (https://doi.org/10.1289/EHP1742). The a...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Conclusions: There was no significant difference in lipid profile itself between two groups, but more importantly the presence of the plaque was much higher indicating possible detrimental effect of AI on cardiovascular system. PMID: 28838227 [PubMed - as supplied by publisher]
Source: The Korean Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Korean J Intern Med Source Type: research
CONCLUSION: Immediate reconstruction with a DIEP flap in the setting of adjuvant radiation therapy is an acceptable approach and appears not to influence the oncologic efficacy of radiation treatment. Further prospective studies are advocated. PMID: 28760638 [PubMed - as supplied by publisher]
Source: Annales de Chirurgie Plastique et Esthetique - Category: Cosmetic Surgery Authors: Tags: Ann Chir Plast Esthet Source Type: research
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