Nephrin-Binding Ephrin-B1 at the Slit Diaphragm Controls Podocyte Function through the JNK Pathway

Conclusions Through interactions with nephrin, ephrin-B1 maintains the structure and barrier function of the slit diaphragm. Moreover, phosphorylation of ephrin-B1 and, consequently, JNK are involved in the development of podocyte injury.

Source: Journal of the American Society of Nephrology : JASN - April 30, 2018 Category: Urology & Nephrology Authors: Fukusumi, Y., Zhang, Y., Yamagishi, R., Oda, K., Watanabe, T., Matsui, K., Kawachi, H. Tags: Basic Research Source Type: research