Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells

During the lifetime of an animal, hematopoietic stem cells (HSCs) are exposed to various insults, such as genotoxic stress, inflammation, and infection, which directly affect HSCs. These insults deplete HSCs and cause a functional decline in HSCs, and also promote their aging and transformation [1 –3]. However, the impact of hematopoietic insults on niche cells remains largely unknown.

Source: Experimental Hematology - April 27, 2018 Category: Hematology Authors: Sha Si, Yaeko Nakajima-Takagi, Takahito Iga, Mayoko Tsuji, Libo Hou, Motohiko Oshima, Shuhei Koide, Atsunori Saraya, Satoshi Yamazaki, Keiyo Takubo, Yoshiaki Kubota, Tohru Minamino, Atsushi Iwama Tags: Regular article Source Type: research