Sperm Sorting Device Developed At WPI May Improve Fertility Treatments

WORCESTER (CBS) – About 15-percent of couples experience infertility in the U.S. and at least a third of cases are due to male reproductive issues. But some local researchers have developed a sperm sorting device which may help couples trying to conceive improve their chances. When couples undergo fertility treatments such as in vitro fertilization (IVF), embryologists try to select the best sperm to use. That often involves a spinning process much like clothes in a washing machine, but those high forces can cause damage to the sperm and the DNA inside. “The less we subject the cells to outside forces, outside effects, the healthier that we have a chance of isolating the healthy ones,” says Erkan Tuzel, PhD, an associate professor of physics at Worcester Polytechnic Institute (WPI). Tuzel’s team and colleagues at Stanford University have created a device called SPARTAN (Simple Periodic ARray for Trapping And IsolatioN). It’s the size of a credit card and can sort out the healthiest sperm in a simple, gentle, and efficient way. Resembling an obstacle course, the device is made up of a series of 3-dimensional columns for sperm to swim around. Only the healthiest make it to the end the fastest. An animated description of the sperm sorting device. (Image credit: Erkan Tuzel – WPI) “[It’s] a physical maze that we have designed that essentially helps the healthy sperm to leave a flock behind, a flock of maybe unhealthy or not abl...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated Local Dr. Mallika Marshall Local TV Sperm Sorter Source Type: news

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Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
CONCLUSION: Elective oocyte cryopreservation is a feasible option for successful pregnancy in patients opposed to embryo cryopreservation. PMID: 30408388 [PubMed]
Source: Journal of Reproductive Medicine - Category: Reproduction Medicine Tags: J Reprod Med Source Type: research
Authors: Hudecek R, Huser M, Pdnkovi S, Mekiniovi L, Kadlecovi J, Ventruba P Abstract OBJECTIVE: To determine the efficacy and safety of intramyometrial application of epinephrine during a laparoscopic myomectomy in women of reproductive age desiring pregnancy and with clinically symptomatic uter- ine fibroids, in comparison with a placebo-based patient control group. STUDY DESIGN: The study group (n=96, 53.3%) underwent an application of 12 μg epinephrine hydro- chloride diluted in 20 mL of NaCl solution, while the control group (n=84, 46.7%) received 20 mL of NaCl only. Perioperative blood loss, duration o...
Source: Journal of Reproductive Medicine - Category: Reproduction Medicine Tags: J Reprod Med Source Type: research
Authors: Bhalani V, Chang A, Adkins C, Chen SH, Scheiber M Abstract OBJECTIVE: To assess fertility outcomes in infertile women after hysteroscopic morcellation of intrauterine lesions. STUDY DESIGN: Retrospective case series from 2 U.S. fertility clinics. Women with intrauterine pathology and infertility (≥6 months' duration if age ≥35, or ≥12 months' duration if age
Source: Journal of Reproductive Medicine - Category: Reproduction Medicine Tags: J Reprod Med Source Type: research
This study aimed at evaluating the effect of combined treatment with myo-inositol, alpha-lipoic acid, folic acid, betaine and vitamins (namely, Sinopol®) on semen parameters of sub-fertile men. PATIENTS AND METHODS: We recruited 143 sub-fertile men, 26-53 years aged, no-smokers, without any testicular pathologies, with a normal endocrinological/metabolic profile, and no concomitant consumption of drugs. Out of them, 25 patients did not meet study inclusion criteria mainly due to the history of genital diseases that came to light after Sinopol® prescription. Among the 118 men that fulfilled inclusion criteria, 1...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
This article provides a detailed characterization of the belief that modern contraceptives cause infertility, and an examination of how this belief arises and spreads, and why it is so salient. We conducted focus group discussions and key informant interviews in three rural communities along Kenya's eastern coast, and identified the following themes: (1) the belief that using modern contraception at a young age or before childbirth can make women infertile is widespread; (2) according to this belief, the most commonly used methods in the community were linked to infertility; (3) when women observe other women who cannot ge...
Source: Studies in Family Planning - Category: International Medicine & Public Health Authors: Tags: ARTICLE Source Type: research
Contributors : Sylvia C Hewitt ; Rong Li ; Nyssa Adams ; Wipawee Winuthayanon ; Katherine J Hamilton ; Lauren J Donoghue ; Sydney L Lierz ; Marleny Garcia ; John P Lydon ; Francesco J DeMayo ; Karen Adelman ; Kennest S KorachSeries Type : Expression profiling by arrayOrganism : Mus musculusPausing of RNA polymerase II (Pol II) during early transcription, mediated by the negative elongation factor (NELF) complex, allows cells to coordinate and appropriately respond to signals by modulating the rate of transcriptional pause release. Promoter proximal enrichment of Pol II occurs at uterine genes relevant to reproductive biolo...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
myLAB Box, a healthcare company based in California, has developed and pioneered an at-home sexually transmitted disease (STD) testing service. With the number of STDs rising, the Centers for Disease Control and Prevention estimates that nearly 20 mi...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Medicine Public Health Reproductive Medicine Source Type: blogs
CONCLUSION: Unexplained infertility patients who underwent LET stimulation with IC werefound to have better pregnancy out- comes as compared to those who underwent timed IC.or IUI with CC stimulation. PMID: 30383939 [PubMed]
Source: Journal of Reproductive Medicine - Category: Reproduction Medicine Tags: J Reprod Med Source Type: research
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Source: African Journal of Reproductive Health - Category: African Health Tags: Afr J Reprod Health Source Type: research
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