fMRI shows dementia patients' brain response to music
Functional MRI (fMRI) has shown that when you get an uplifting feeling from...Read more on AuntMinnie.comRelated Reading: fMRI offers clues about memory loss in older adults fMRI, machine learning could predict OCD therapy outcomes fMRI shows what makes an angry drunk fMRI, PET could help foresee epileptic seizure issues fMRI helps guide therapy designed to reduce tinnitus
Authors: Yin Y, Wang Z Abstract Age and apolipoprotein E (ApoE) are the mightiest risk factors for dementia and cardiovascular diseases, but the underlying mechanisms remain unclear. In human, ApoE has three isoforms, ApoE2, ApoE3, and ApoE4, which are expressed by the polymorphic alleles: ɛ2, ɛ3, and ɛ4. Among the three polymorphic alleles, apoE ε4 is the most risk gene. ApoE is the main ligand for the low-density lipoprotein (LDL) receptor and the LDL receptor-related protein (LRP), functioning as the component of plasma lipoproteins in the transportation of lipids. Physiologically, ApoE is a multifunc...
ConclusionA new robust and reliable rating scale is described that straightforwardly captures the visual appearance of 123I-Ioflupane brain images. It demonstrated high accuracy in autopsy confirmed cases and offers advantages over the existing visual rating scale.
Authors: Vossler DG, Weingarten M, Gidal BE, American Epilepsy Society Treatments Committee PMID: 30233275 [PubMed]
In this study, effects of melatonin on cognitive impairment and related mechanisms were investigated in an animal model of ischemic vascular dementia (IVD). Melatonin was intraperitoneally administered to adult gerbils after transient global cerebral ischemia (tGCI) for 25 days beginning 5 days after tGCI. Cognitive impairment was examined using a passive avoidance test and the Barnes maze test. To investigate mechanisms of restorative effects by melatonin, neuronal damage/death, myelin basic protein (MBP, a marker for myelin), Rip (a marker for oligodendrocyte), extracellular signal-regulated protein kinase1/2 (ERK1/2) an...
For the estimated 5 million seniors in the U.S. diagnosed with dementia natural disasters can be particularly terrifying.
Publication date: Available online 20 September 2018Source: International Review of NeurobiologyAuthor(s): Nicolaas I. Bohnen, Prabesh Kanel, Martijn L.T.M. MüllerAbstractOne of the first identified neurotransmitters in the brain, acetylcholine, is an important modulator that drives changes in neuronal and glial activity. For more than two decades, the main focus of molecular imaging of the cholinergic system in Parkinson's disease (PD) has been on cognitive changes. Imaging studies have confirmed that degeneration of the cholinergic system is a major determinant of dementia in PD. Within the last decade, the focus is...
Dementia UK has revealed people diagnosed with Alzheimer's are most often worried about having to stop driving, giving up work, losing their memory and needing someone to manage their money.
This article originally appeared on Kaiser Health News (KHN), a nonprofit news service covering health issues. It is an editorially independent program of the Kaiser Family Foundation that is not affiliated with Kaiser Permanente.
Condition: Epilepsy Intervention: Drug: sodium valproate Sponsor: Sanofi Not yet recruiting
Condition: Dementia Intervention: Behavioral: Dementia symptom management at home hospice edition Sponsors: New York University School of Medicine; National Institutes of Health (NIH) Not yet recruiting