Reductions in otitis and other respiratory tract infections following childhood pneumococcal vaccination

Acta Paediatrica, EarlyView.
Source: Acta Paediatrica - Category: Pediatrics Authors: Source Type: research

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Publication date: Available online 19 May 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Chih-Ho Chen, Chyi-Liang Chen, Adriano Agueras, Jo Southern, Chang-Chun Hsiao, Cheng-Hsun Chiu
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
ConclusionsCanadian PCV programs have provided significant health benefits and resulted in a substantial value for money. Net savings achieved over the reviewed period would have provided funding for $1.76  billion in other health care costs or public health initiatives. These findings highlight the importance of considering the total value of a vaccination program, rather than vaccine acquisition costs only, when assessing the value of immunization programs.
Source: Infectious Diseases and Therapy - Category: Infectious Diseases Source Type: research
Abstract BACKGROUND: Otitis is a frequently occurring condition in young children and involves considerable use of antibiotics. The most common bacterial cause is pneumococci. The pneumococcal vaccine was introduced as part of the Childhood Immunisation Programme in Norway in 2006. The purpose of the study was to investigate whether this vaccination may have reduced the number of otitis cases presenting at emergency primary health care units. MATERIAL AND METHOD: The material consists of data from all electronic reimbursement claims from emergency primary health care doctors in the period 2006-18. Annual cons...
Source: Tidsskrift for den Norske Laegeforening - Category: General Medicine Authors: Tags: Tidsskr Nor Laegeforen Source Type: research
Streptococcus pneumoniae is a leading cause of childhood morbidity and mortality worldwide (O ’Brien et al., 2009). In 2000, it was estimated that 14.5 million episodes of serious pneumococcal disease occurred, causing 826 000 deaths in children, with over 61% of deaths occurring in African and Asian countries. Since 2000, protein–polysaccharide conjugate vaccines targeting pneumococcal serotypes have been introduced for use in children. Following its widespread use, the 7-valent pneumococcal conjugate vaccine (PCV7) has substantially reduced the incidence of invasive pneumococcal infection, and hospital admiss...
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Blue Water Vaccines Inc., a Norwood startup, has entered into an exclusive worldwide license agreement with St. Jude Children ’s Research Hospital to develop a vaccine for Streptococcus pneumoniae. The bacteria can cause many kinds of diseases, including the lung infection pneumonia. “A major limitation of the currently licensed pneumococcal vaccines is the lack of efficacy against mucosal disease manifestations such as acute otitis media, acute bacterial sinusitis and pneumonia,” Blue Water…
Source: Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Conclusion Micro-otoscopy should be included in the routine work-up of any suspected adult meningitis, because OgM is underdiagnosed. Unlike their impact on pediatric otitis media, PCVs did not change the epidemiology and bacteriology of OgM. [...] Thieme Revinter Publicações Ltda Rio de Janeiro, BrazilArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: International Archives of Otorhinolaryngology - Category: ENT & OMF Authors: Tags: Original Research Source Type: research
Opisthotonos, extreme involuntary neck and back extension, is rarely seen in modern emergency departments. Vaccines have prevented the most common causes of this clinical presentation. Alternatively, otitis media is one of the most common pediatric infections and is characteristically non-invasive and harmless. In exceedingly rare cases, otitis media can develop complications and progress to invasive pneumococcal diseases including mastoiditis and meningitis. Streptococcus pneumoniae accounts for the majority of otitis media infections, however, since the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) a...
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
Conclusions: Presence of bacterial otopathogen, specifically nontypeable H. influenzae, in the middle ear during VTI was a predictor of children at-risk of repeat VTI. Here, we identify a modifiable microbiologic factor for repeat VTI that can be targeted to improve clinical management of rAOM.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
Conclusion: According to WHO-recommended thresholds for interpreting cost-effectiveness, introduction of PCV-13 for children under 5 years in the Islamic Republic of Iran would be cost-effective. PMID: 31774134 [PubMed - in process]
Source: Eastern Mediterranean Health Journal - Category: Middle East Health Tags: East Mediterr Health J Source Type: research
Outbreaks of severe pneumococcal disease occur sporadically and can affect large numbers of individuals, although they are less frequent compared to the pre-antibiotic era.1 The responsible pathogen, Streptococcus pneumoniae, is a Gram-positive bacterium that commonly colonises the nasopharyngeal tract, especially in young children. Occasionally, however, it can invade locally to cause mucosal infections including sinusitis, otitis media or pneumonia. Rarely, invasion of the bloodstream can lead to more serious infections, including septicaemia and meningitis.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
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