828 Reversal of a core, keratinocyte-autonomous inflammatory program linking diverse cutaneous rashes

Critical transcriptional programs specify epidermal differentiation; their disruption leads to diverse skin pathology ranging from impaired barrier function to pathogenic inflammation. We constructed a high-resolution map of this complex cellular reprogramming, using single-cell RNA sequencing profiles of more than 150,000 human epidermal keratinocytes from different anatomic sites and also inflamed skin. These data reveal a novel, subcorneal compartment-specific inflammatory program shared by previously unlinked, diverse inflammatory diseases such as psoriasis, erythrokeratodermia variablis, and xerotic eczema.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research