1120 Spironolactone depletes XPB protein and inhibits the UVB DNA damage response in human skin

A recent high throughput screen of FDA-approved drugs that modulate UV photoproduct removal identified spironolactone (SP) as an inhibitor of nucleotide excision repair (NER) in HeLa cells via its ability to promote the rapid proteolytic degradation of the core NER protein XPB (xeroderma pigmentosum group B). Because SP is used clinically to treat hormonal acne and other conditions, we examined whether the drug similarly affects XPB protein levels in cultured human keratinocytes in vitro and human skin explants ex vivo.

Source: Journal of Investigative Dermatology - April 27, 2018 Category: Dermatology Authors: M.G. Kemp, J.B. Travers Tags: Photobiology Source Type: research