Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland

Finland provides unique opportunities to investigate population and medical genomics because of its adoption of unified national electronic health records, detailed historical and birth records, and serial population bottlenecks. We assembled a comprehensive view of recent population history ( ≤100 generations), the timespan during which most rare-disease-causing alleles arose, by comparing pairwise haplotype sharing from 43,254 Finns to that of 16,060 Swedes, Estonians, Russians, and Hungarians from geographically and linguistically adjacent countries with different population histori es.

Source: The American Journal of Human Genetics - April 26, 2018 Category: Genetics & Stem Cells Authors: Alicia R. Martin, Konrad J. Karczewski, Sini Kerminen, Mitja I. Kurki, Antti-Pekka Sarin, Mykyta Artomov, Johan G. Eriksson, T õnu Esko, Giulio Genovese, Aki S. Havulinna, Jaakko Kaprio, Alexandra Konradi, László Korányi, Anna Kostareva, Minna Männik Tags: Article Source Type: research