Distinct T-helper cell responses to Staphylococcus aureus bacteremia reflect immunologic comorbidities and correlate with mortality

The dysregulated host immune response that defines sepsis varies as a function of both the immune status of the host and the distinct nature of the pathogen. The degree to which immunocompromising comorbiditie...
Source: Critical Care - Category: Intensive Care Authors: Tags: Research Source Type: research

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This study was therefore aimed to assess the in vitro bioactivities associated with the LP EO. The EO was separated by hydrodistillation from the aerial parts of LP plants and analyzed for its antioxidant, antimicrobial, anticholinesterase, and antilipase activities. GC-MS was used for phytochemical analysis. The chemical analysis of the EO composition revealed 25 constituents, of which carvacrol (65.27%) was the most abundant. EO exhibited strong antioxidant (IC50 0.16-0.18 μL/mL), antiacetylcholinesterase (IC50 0.9 μL/mL), antibutyrylcholinesterase (IC50 6.82 μL/mL), and antilipase (IC50 1.0...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Chem. Commun., 2020, Advance Article DOI: 10.1039/C9CC09166A, CommunicationYue Zhang, Gaoxi Cui, Nana Qin, Xijuan Yu, Hui Zhang, Xiaofei Jia, Xiaohua Li, Xuzhi Zhang, Xu Hun A self-catalytic ampicillin –metal (Fe3+)-organic gels (AMP –MOGs (Fe))–H2O2 CL system, which is not influenced by transition metal ions, was studied. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Abstract Prosthetic joint infection (PJI) is one of the most devastating failures in total joint replacement (TJR). Infections are becoming difficult to treat due to the emergence of multi-drug resistant bacteria. These bacteria produce biofilm on the implant surface, rendering many antibiotics ineffective by compromising drug diffusion and penetration into the infected area. With the introduction of new antibiotics there is a need to create benchmark data from the traditional antibiotic loaded bone cements. Vancomycin, one of the commonly used antibiotics, shows activity against Methicillin-resistant Staphylococc...
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
AbstractThe aim of the present study was to identify predictors of fatality among patients withS. aureus infections requiring hospitalization. Cases hospitalized withS. aureus infections at the University General Hospital of Patras, Greece, during a 4-year period (2013 –2016) were studied.mecA, lukS/lukF-PV (Panton-Valentine leukocidin, PVL),tst (toxic shock syndrome toxin),fnbA (fibronectin-binding protein A),eta, andetb (epidermolytic toxins) genes ’ carriage was detected by PCR in 149 selected patients. Among 464 patients, 346 were included (118 with missing data). Primary bacteremia predominated (44.2%), fo...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
It is well-established that the spread of many multidrug-resistant (MDR) bacteria is predominantly clonal. Interestingly the international clones/sequence types (STs) of most pathogens emerged and disseminated during the last three decades. Strong experimental evidence from multiple laboratories indicate that diverse fitness cost associated with high-level resistance to fluoroquinolones contributed to the selection and promotion of the international clones/STs of hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA), extended-spectrum β-lactamase-(ESBL)-producing Klebsiella pneumoniae, ESBL-produci...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
AbstractPurposeThe purpose of this study was to describe left-sided infective endocarditis (LSIE) in persons who inject drugs (PWID) and compare that group to PWID with non-LSIE and to non-PWID with LSIE.MethodsRetrospective single-center study of adult IE patients from 2011 to 2018.ResultsOf the 333 patients in our cohort, 54 were PWID with LSIE, 75 were PWID with non-LSIE, and 204 were non-PWID with LSIE. When comparing LSIE vs non-LSIE in PWID, the LSIE group was older (median age 35 vs 28.5,p 
Source: Infection - Category: Infectious Diseases Source Type: research
Contributors : Samuel Jacques ; Almer M van der Sloot ; Caroline Huard ; Jasmin Coulombe-Huntington ; Sarah Tsao ; Sylvain Tollis ; Thierry Bertomeu ; Elizabeth J Culp ; Daniel Pallant ; Michael A Cook ; Eric Bonneil ; Pierre Thibault ; Gerard D Wright ; Michael TyersSeries Type : OtherOrganism : Homo sapiensSystematic genetic interaction profiles can reveal the mechanism-of-action of bioactivecompounds. The imipridone ONC201, which is currently in cancer clinical trials, has beenascribed a variety of different targets. To investigate the genetic dependencies of imipridoneaction, we screened a genome-wide CRISPR knockout l...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Molecular typing methods are useful for rapid detection and control of a disease. Recently, the use of high-resolution melting (HRM) for spa typing of MRSA isolates were reported. This technique is rapid, inexpen...
Source: BMC Research Notes - Category: Research Authors: Tags: Research note Source Type: research
Julichrome Monomers from Marine Gastropod Mollusk-Associated Streptomyces and Stereochemical Revision of Julichromes Q3·5 and Q3·3. Chem Biodivers. 2020 Feb 24;: Authors: Dong Y, Ding W, Sun C, Ji X, Ling C, Zhou Z, Chen Z, Chen X, Ju J Abstract Two julichrome monomers, julichromes Q 11 ( 1 ) and Q 12 ( 2 ), along with five known julichromes [Q 10 ( 3 ), Q 3.5 ( 4 ), Q 3·3 ( 5 ), Q 6·6 ( 6 ), Q 6 ( 7 )] and four known anthraquinones [chrysophanol ( 8 ), 4-acetylchrysophanol ( 9 ), islandicin ( 10 ), huanglongmycin A ( 11 )], were isolated from the marine gastropod mollusk B...
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research
Microbial Drug Resistance, Ahead of Print.
Source: Microbial Drug Resistance - Category: Microbiology Authors: Source Type: research
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