AAN 2018: Lilly's Galcanezumab Significantly Reduced Monthly Migraine Headache Days in Patients with Migraine Who Previously Failed to Respond to Multiple Preventive Therapies

INDIANAPOLIS, April 24, 2018 -- (Healthcare Sales &Marketing Network) -- Eli Lilly and Company (NYSE: LLY) announced today results from a post-hoc subgroup analysis which demonstrated efficacy of galcanezumab in patients with episodic and chronic migrain... Biopharmaceuticals, Neurology Eli Lilly, galcanezumab, migraine
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news

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BACKGROUND: Electronic harassment affects 20-40% of adolescents and has been associated with significant negative outcomes including physical (ex. headache, abdominal pain), psychological (ex. depression, anxiety), and psychosocial (ex. school avoidance) p...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
(Natural News) In an article in People.com, Dr. Howard A. Riina, Professor of Neurology at NYU Langone Medical Center said that a brain aneurysm feels like the“worst headache of someone’s life”. Even those with a history of migraines or headaches have described the sensation as feeling like a lightning strike. “It’s this severe, severe headache...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Authors: Nehra V, Rizza SA, Temesgen Z Abstract The fixed-dose combination of glecaprevir (GLE), a nonstructural protein 3/4A (NS3/4A) protease inhibitor, and pibrentasvir (PIB), an NS5A inhibitor, was recently approved for the treatment of adult patients with chronic hepatitis C virus (HCV) genotypes 1-6 (GT-1-6) without cirrhosis or with compensated cirrhosis, and for the treatment of HCV GT-1 patients who have failed treatment with either NS5A inhibitors or NS3/4A protease inhibitors, but not both. This combination, administered over 8 or 12 weeks, has resulted in high cure rates in all six HCV genotypes, includ...
Source: Drugs of Today - Category: Drugs & Pharmacology Tags: Drugs Today (Barc) Source Type: research
ElectroCore said yesterday it inked a collaborative research deal with Massachusetts General Hospital exploring the use of ElectroCore’s non-invasive vagus nerve stimulation tech in targeted treatments for neuroinflammation. The Basking Ridge, N.J.-based company said that investigators will examine the effects the nVNS system has on neuroinflammatory mechanisms associated with conditions in the central nervous system including pain, trauma and neurodegeneration. ElectroCore said it will supply up to $1 million through a research grant over four years to support preclinical trials of the device, including work al...
Source: Mass Device - Category: Medical Devices Authors: Tags: Clinical Trials Neurological Neuromodulation/Neurostimulation electroCore Source Type: news
Frequent or continuous headache is common after head trauma. This review outlines key clinical characteristics of posttraumatic headache, its pathophysiology, and its optimal management.Headache
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news
CONCLUSION: the history we report, therefore, confirms previous experiences reporting a possible favourable outcome of pregnancy in patients affected by acromegaly and add further information about the behaviour of giant pituitary tumors in patients underwent pregnancy. PMID: 30088454 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Abstract The relationship of sleep and migraine is unequivocal and familiarity with the nature and magnitude of these associations may inform clinical practice. Recent prospective, longitudinal, and time-series analysis has begun to unravel the magnitude and temporal patterns of sleep and migraine. Prospective evidence has shown that sleep variables can trigger acute migraine, precede and predict new onset headache by several years, and indeed, sleep disturbance and snoring are risk factors for chronification. The presence of a sleep disorder is associated with more frequent and severe migraine and portends a poor...
Source: Headache - Category: Neurology Authors: Tags: Headache Source Type: research
Sometimes, it is fairly safe to assume that a patient is more likely to have a familial disorder than a sporadic form of the same disease. A 39-year-old man was brought to the emergency department by ambulance with chest pain and palpitations. He had a history of migraines and dyspepsia. His family history was remarkable for a sister with Wolff-Parkinson-White syndrome, detected at age 18 years during pregnancy, and a brother with Wolff-Parkinson-White syndrome. The patient's son, born prematurely, was diagnosed with Wolff-Parkinson-White syndrome at 1 month of age, and he underwent ablation therapy when he was 8 years old.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: ECG image of the month Source Type: research
When the patient's autoimmune disorder didn't respond to treatment, an additional workup uncovered a malignancy; one with an undefined connection. A 73-year-old woman presented with fatigue, left upper quadrant pain, headache, nausea, and cognitive dysfunction. An initial workup revealed  hypercalcemia, a low level of parathyroid hormone, elevated levels of angiotensin converting enzyme and alkaline phosphatase, pancytopenia, and mediastinal lymphadenopathy (Table 1). While magnetic resonance imaging (MRI) of her brain produced unremarkable results, abdominal imaging showed tra ce ascites, mil...
Source: The American Journal of Medicine - Category: General Medicine Authors: Source Type: research
AbstractMany  central nervous system diseases currently lack effective treatment and are often associated with defects in microvascular function, including a failure to match the energy supplied by the blood to the energy used on neuronal computation, or a breakdown of the blood–brain barrier. Pericytes, an u nder-studied cell type located on capillaries, are of crucial importance in regulating diverse microvascular functions, such as angiogenesis, the blood–brain barrier, capillary blood flow and the movement of immune cells into the brain. They also form part of the “glial” scar isolating dam...
Source: Acta Neuropathologica - Category: Neurology Source Type: research
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