Retro Report: A Drug to End Addiction? Scientists Are Working on It.

Researchers are studying a promising drug that could block the delivery of opioids from blood to brain, giving addicts a path to recovery.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Opioids and Opiates Drug Abuse and Traffic Addiction (Psychology) Heroin Vaccination and Immunization Source Type: news

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Publication date: July 2018Source: Nanomedicine: Nanotechnology, Biology and Medicine, Volume 14, Issue 5Author(s): Zongmin Zhao, Yun Hu, Theresa Harmon, Paul R. Pentel, Marion Ehrich, Chenming ZhangAbstractA series of hybrid nanoparticle-based nicotine nanovaccines (NanoNicVac) were engineered in this work by conjugating potent carrier protein candidates (Keyhole limpet hemocyanin (KLH) multimer, KLH subunit, cross-reactive material 197 (CRM197), or tetanus toxoid (TT)) for enhanced immunological efficacy. NanoNicVac with CRM197 or TT were processed by dendritic cells more efficiently than that with KLH multimer or subuni...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
AbstractReceptive anal intercourse, multiple partners, condomless sex, sexually transmitted infections (STIs), and drug/alcohol addiction are familiar factors that correlate with increased human immunodeficiency virus (HIV) risk among men who have sex with men (MSM). To improve estimation to HIV acquisition, we created a composite score using questions from routine survey of 3588 MSM in Beijing, China. The HIV prevalence was 13.4%. A risk scoring tool using penalized maximum likelihood multivariable logistic regression modeling was developed, deploying backward step-down variable selection to obtain a reduced-form model. T...
Source: AIDS and Behavior - Category: Infectious Diseases Source Type: research
This study was conducted to determine if immunopharmacotherapy directed against oxycodone would be capable of altering oxycodone-induced antinociception and intravenous self-administration. Male Wistar rats were administered a small-molecule immunoconjugate vaccine (Oxy-TT) or the control carrier protein, tetanus toxoid (TT), and trained to intravenously self-administer oxycodone (0.06 or 0.15 mg/kg/infusion). Brain oxycodone concentrations were 50% lower in Oxy-TT rats compared to TT rats 30 min after injection (1 mg/kg, s.c.) whereas plasma oxycodone was 15-fold higher from drug sequestration by circulating antibod...
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Neuropharmacology Source Type: research
By Lloyd I. Sederer, MD, author of The Addiction Solution: Treating Our Dependence on Opioids and Other Drugs (out now on Simon &Schuster) It’s clear to me, as a public health doctor and journalist, that there have been fewer news stories on the opioid epidemic in recent months, in print, online, and on the radio and TV. While I don’t have a major survey to point to, my work demands that I pay attention to this epidemic and the stories written about it — and that I encourage others to take it seriously as well. Have we grown numb to the people who are dying every day? To the families thrown into ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health opioid epidemic Simon & Schuster Source Type: news
April 2-8 marks ​National Public Health Week (NPHW). Each day is marked with a specific public health theme:Monday, April 2: Behavioral HealthAdvocate for and promote well-beingFocus on and advocate for improved access to mental and behavioral health services. Use education and training to de-stigmatize mental health diagnoses and encourage people experiencing mental illness to seek treatment. Coverage for mental health services must be on par with physical health services in all health insurance coverage.Tuesday, April 3: Communicable DiseasesLearn about ways to prevent disease transmissionWash your hands. Know your HIV...
Source: Medicine and Technology by Dr. Joseph Kim - Category: Information Technology Source Type: blogs
Vaccines could help prevent relapses but have yet to be effective in clinical trials
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
Lately my dander is up so often and so copiously, over what's happening in health care and the world at large, I'm exhausted. Covered with nasty dander. Cowering under the sheets. Others seem to share this dysphoria. But I found if not a cure, at least a palliative. There's so much dander I can scrape it off with a great big shovel and toss as much as I can your way. Here's my first DanderOmnium Gatherum, or DOG, from the Cetona DOG Patch. Remember, these stories are all DOGs.Litmus Test for New HHS Secretary. The new sheriff at Health&Human Services, Alex Azar, has barely had a chance to wipe his feet in front of...
Source: Health Care Renewal - Category: Health Management Source Type: blogs
In May 2017, the second European Respiratory Society research seminar of the Thoracic Oncology Assembly entitled "Immunotherapy, a new standard of care in thoracic malignancies?" was held in Paris, France. This seminar provided an opportunity to review the basis of antitumour immunity and to explain how immune checkpoint inhibitors (ICIs) work. The main therapeutic trials that have resulted in marketing authorisations for use of ICIs in lung cancer were reported. A particular focus was on the toxicity of these new molecules in relation to their immune-related adverse events. The need for biological selection, cur...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Perspective Source Type: research
(Scripps Research Institute) Scientists at The Scripps Research Institute (TSRI) have achieved a major milestone toward designing a safe and effective vaccine to both treat heroin addiction and block lethal overdose of the drug.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
This study aims to identify the epidemiological features of HBV among pregnant Iranian women. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Two authors independently searched several online databases without time limit until May 2017. The databases include Magiran, Iranmedex, SID, Medlib, IranDoc, Scopus, PubMed, Science Direct, Cochrane, Web of Science and Google Scholar. The data were analyzed based on a random-effects model using Comprehensive Meta-Analysis software version 2. Thirty-seven studies were included in the meta-analysis. The prevalence of HBV ...
Source: Archives of Virology - Category: Virology Source Type: research
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