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UK study to track progression of chronic kidney disease

Researchers behind a major new study of chronic kidney disease hope it will provide vital information to aid earlier diagnosis and treatment.
Source: Nursing Times - Category: Nursing Source Type: news

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ConclusionsControlled clinical trials are needed to determine which populations may profit from more frequent potassium-monitoring and subsequent interventions, e.g., change or withdrawal of potassium-influencing drugs, in order to restore normal values and prevent cardiovascular outcomes.Registration DetailsRegistration in PROSPERO (Centre for Reviews and Dissemination University of York, York, UK): CRD42016048897 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=48897).
Source: Cardiovascular Drugs and Therapy - Category: Cardiology Source Type: research
Authors: Tong L, Adler S Abstract Chronic kidney disease (CKD) is a frequent complication of type 2 diabetes mellitus (T2DM) and elevates individuals' risk for cardiovascular disease, the leading cause of morbidity and mortality in T2DM. Achieving and maintaining tight glycemic control is key to preventing development or progression of CKD; however, improving glycemic control may be limited by effects of renal impairment on the efficacy and safety of T2DM treatments, necessitating dosing adjustments and careful evaluation of contraindications. Understanding the treatment considerations specific to each class of T2D...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Authors: Pitt B, Garza D Abstract INTRODUCTION: Hyperkalemia (HK) occurs often among patients with chronic kidney disease (CKD) and heart failure (HF) and those treated with renin-angiotensin-aldosterone system inhibitors (RAASI). Even small deviations from normal potassium levels carry increased risk of mortality. Patiromer is approved for treatment of HK and has been shown in clinical trials to reduce serum potassium among patients with HK and comorbid conditions. Areas covered: We review pooled data from two clinical trials of patiromer in patients with CKD and HK, safety of patiromer in special populations, dru...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Conclusions: Contrast-enhanced CT upon arrival is suggested, and patients with extravasation on CT would be good candidates for urgent colonoscopy, as well as patients who have a history of CDB and CKD.Digestion 2018;98:41 –47
Source: Digestion - Category: Gastroenterology Source Type: research
Pruritus associated with chronic kidney disease is a distressing condition which has not been rigorously studied using validated patient-reported outcome (PRO) tools. The purpose of this study was to conduct psychometric validation of the Worst Itching Intensity Numeric Rating Scale (NRS), a single item PRO measuring the worst itching severity in the past 24 h on a 0-10-point scale, and to determine the threshold for a clinically meaningful change for this patient population. This analysis was based on data from a phase II randomized, placebo-controlled study which demonstrated the effectiveness of CR845 at reducing modera...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Patient Outcomes Research Source Type: research
Chronic kidney disease-associated pruritus (CKD-aP) is a debilitating chronic itching condition frequently reported in end stage renal disease patients, with no approved treatments in the United States (US). As the sensation of itching can only be assessed by patient report, reliable, valid and sensitive patient-reported outcomes (PROs) are required to demonstrate treatment benefits in studies of therapies under development for treatment of pruritus in hemodialysis (HD) patients. The purpose of this study was to conduct qualitative interviews in HD patients to evaluate the content validity of two existing PRO instruments, ...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Patient Outcomes Research Source Type: research
Patients with chronic kidney disease are commonly afflicted by pruritus, a condition with no treatment approved in the USA. The etiology of this condition is likely multifactorial, including systemic inflammation and deficiency in the endogenous kappa opioid system. CR845 is a novel and full kappa opioid receptor agonist with no off-target activities, including mu- or delta-opioid receptors. In addition to its unique receptor profile, the peptidic structure of CR845 restricts its entry into the central nervous system.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Pharmacology and Drug Development Source Type: research
We thank Dr. Labriola and Dr. Jadoul for their comments.1 We fully agree with the relevance of falls as a major risk factor of fracture in such patients.2 Falls were mentioned and included in Figure  12 as an important determinant of fractures. However, this issue was not extensively discussed because of few relevant data available in chronic kidney disease (CKD) patients. CKD patients, including those treated by dialysis, may have a high propensity for falls. Several factors are probably invo lved, including accelerated aging with deleterious consequences such as impaired cognitive function, neurological disorders, v...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
In their recent review concerning the diagnosis, treatment, and prevention of fractures in chronic kidney disease (CKD) patients, Pimentel et  al.1 point out that the incidence of fractures increases according to CKD stage, with the highest relative risk in patients receiving chronic hemodialysis. The authors underline the high mortality and costs related to fractures in CKD patients and review clinical, biochemical, histological, and st ructural parameters related to bone fragility in CKD. The authors briefly mention but regrettably omit to discuss the occurrence of falls as a crucial determinant for fractures in hemodialysis patients.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
A 44-year-old male patient presented with recurrent urinary tract infections (urine cultures negative) for 2 years. He was diagnosed as having a urethral stricture, and he underwent dilatations. However, his renal functions deteriorated, and he developed chronic kidney disease (CKD) requiring dialysis and transplantation. Pretransplant workup revealed 4 –5 leukocytes on urine examination, proteinuria (0.2 g/d), and a serum creatinine level of 6.7 mg/dl. Magnetic resonance imaging of his kidneys showed multifocal hyperintense lesions in both.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research
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