A role for accelerometry in the differential diagnosis of tremor syndromes.

A role for accelerometry in the differential diagnosis of tremor syndromes. Funct Neurol. 2018 Jan/Mar;33(1):45-49 Authors: Bove F, Di Lazzaro G, Mulas D, Cocciolillo F, Di Giuda D, Bentivoglio AR Abstract Accelerometry is a reliable tool for gauging the occurrence, amplitude and frequency of tremor. However, there is no consensus on criteria for accelerometric diagnosis of tremor syndromes. We enrolled 20 patients with essential tremor (ET), 20 with dystonic tremor (DT), and 20 with classic parkinsonian tremor (PD-T), all meeting accepted clinical criteria. All the patients underwent dopamine transporter imaging (by means of single-photon emission computed tomography) and triaxial accelerometric tremor analysis. The latter revealed groupwise differences in tremor frequency, peak dispersion, spectral coherence, unilaterality and resting vs action tremor amplitude. From the above, five diagnostic criteria were extrapolated for each condition. Receiver operating characteristic curves, depicting criteriabased scoring of each tremor type, showed negligible declines in specificity for scores ≥4 in patients with ET or DT and scores ≥3 in patients with PD-T, thus providing a simple scoring method (accelerometrically derived) for differential diagnosis of the principal tremor syndromes. PMID: 29633696 [PubMed - in process]
Source: Functional Neurology - Category: Neurology Tags: Funct Neurol Source Type: research

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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Brindhaban A Abstract Rationale: Radiation dose to patients from imaging modalities are measured or calculated to assess the risk of the procedure and compared it to the benefits. Periodic review of image acquisition methods and radiation dose used are essential part of procedure optimization in medical imaging. The aim of this study was to estimate patient radiation dose from single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) using computed tomography (CT) images for attenuation correction. Methods: SPECT and CT image acquisition parameters such as, administered activity...
Source: Journal of Nuclear Medicine Technology - Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research
AbstractBackgroundHigher imaging quality makes cardiac positron emission tomography (PET) desirable for evaluation of suspected coronary artery disease (CAD). High cost of PET imaging may be offset by reduced utilization and/or improved outcomes.MethodsThis retrospective observational study utilized Medicare fee-for-service dataset. Study participants had no CAD diagnosis within 1  year prior to initial imaging. The PET group (PET imaging) and propensity score matched comparison group (single photon emission computed tomography or stress echocardiography) underwent index imaging between January 2014 and December 2016....
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
The increased expression of gonadotropin releasing hormone receptor (GnRH ‐R) in brain has been strongly linked to Alzheimer´s disease. Therefore, the development of radiolabeled imaging agents for GnRH‐R is relevant for early diagnosis of Alzheimer`s disease. We have recently disclosed the discovery of two promising compounds displaying nanomolar‐range affinity fo r the GnRH‐R. In the present study, a preclinical evaluation of the compound properties was performed to evaluate their potential as Single Photon Emission Computed Tomography (SPECT) radiotracers for imaging the GnRH‐receptor. The compounds were...
Source: Journal of Labelled Compounds and Radiopharmaceuticals - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research
Authors: Loudos G, Georgiou M, Rouchota M, Papadimitroulas P, Fysikopoulos E Abstract BACKGROUND: For every new drug,>10,000 candidate molecules are tested for ~15 years. This is the daily mission of thousands research teams worldwide. It is well proven that small animal imaging speeds up this work, increases accuracy and decreases costs. However, commercial imaging systems have high purchase cost, require high service contracts, special facilities and trained staff. Thus, they are affordable to only few large research centres and not to the majority of small and medium research teams internationally. There are ...
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
CONCLUSION: The low agreement between amyloid PET/CT and previous clinical and instrumental assessments that we found in our study suggests that the amyloid PET/CT provides additional and early information. To perform an early and differential diagnosis of AD could have a great impact on the patient's management and cost of care in order to perform the correct therapeutic interventions and to allow family members to manage adequately the patient's demanding care. PMID: 31802055 [PubMed - in process]
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
CONCLUSION: Our results indicated that the quantitative accuracy of bone SPECT images was affected by reconstruction parameters. It is important to optimize the reconstruction parameters, and improve quantitative accuracy in bone SPECT imaging. PMID: 31802053 [PubMed - in process]
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
Objectives To evaluate the utility of sequential F-18 fluorodeoxyglucose PET/diffusion-weighted imaging in assessing myocardial perfusion and viability in coronary artery disease. Methods Fourteen coronary artery disease patients and five non-coronary artery disease subjects underwent sequential cardiac F-18 fluorodeoxyglucose PET/diffusion-weighted imaging using a trimodality PET/computed tomography-MRI system. The perfusion data were acquired by measuring low b-values apparent diffusion coefficient using diffusion-weighted imaging. Regional myocardial viability was determined by perfusion/metabolism patterns. The pe...
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Abstract Positron emission tomography (PET) and single photon emission computed tomography (SPECT) are powerful molecular imaging methods for examining disease-related factors in the whole body using specific imaging probes. Recently, we tried to develop molecular imaging probes that specifically visualize pathological factors associated with cancers and infectious diseases. Although survivin is highly expressed in several cancers, its expression is undetectable in non-dividing tissues. Thus, we developed several small molecular imaging probes that target survivin. These ligands not only showed high affinity for s...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
Abstract Primary graft dysfunction after lung transplantation, a consequence of ischemia-reperfusion injury (IRI), is a major cause of morbidity and mortality. IRI involves acute inflammation and innate immune cell activation, leading to rapid infiltration of neutrophils. Formyl peptide receptor 1 (FPR1) expressed by phagocytic leukocytes plays an important role in neutrophil function. The cell surface expression of FPR1 is rapidly and robustly up-regulated on neutrophils in response to inflammatory stimuli. Thus, we hypothesized that use of 99mTc-cFLFLF, a selective FPR1 peptide ligand, would permit in vivo neutr...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - Category: Cytology Authors: Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research
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