KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity

Herndler-Brandstetter et  al. demonstrate that KLRG1+IL-7Rα+ effector CD8+ T cells downregulate KLRG1 in a Bach2-dependent manner and differentiate into long-lived circulating and tissue-resident “exKLRG1” memory cells. Developmental plasticity of KLRG1+ effector cells therefore drives functional diversity within mem ory T cell lineages and promotes enhanced anti-influenza and anti-tumor immunity.

Source: Immunity - April 3, 2018 Category: Allergy & Immunology Authors: Dietmar Herndler-Brandstetter, Harumichi Ishigame, Ryo Shinnakasu, Valerie Plajer, Carmen Stecher, Jun Zhao, Melanie Lietzenmayer, Lina Kroehling, Akiko Takumi, Kohei Kometani, Takeshi Inoue, Yuval Kluger, Susan M. Kaech, Tomohiro Kurosaki, Takaharu Okada Tags: Article Source Type: research