Mp10-02 plasminogen activator inhibitor-1 (pai-1) expression promotes fibrotic renal tubular dysfunction

Plasminogen activator inhibitor-1 (PAI-1) expression is highly upregulated in tubular and interstitial cells during obstructive uropathy (i.e., nephrolithiasis, ureteral stricture) and is linked to kidney fibrosis. Precise mechanisms whereby PAI-1 contributes to renal injury, however, are unknown and, surprisingly, appear to be urokinase-type plasminogen activator independent. Here, we test the hypothesis that sustained PAI-1 expression in renal epithelial cells promotes renal tubular dysfunction and maladaptive repair critical for chronic kidney disease progression.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Infections/Inflammation/Cystic Disease of the Genitourinary Tract: Kidney & Bladder I Source Type: research