Tumour-derived GM-CSF promotes granulocyte immunosuppression in mesothelioma patients.

CONCLUSIONS: Our study presents the mechanism behind the cross-talk between mesothelioma and the immune micro-environment and indicates that targeting GM-CSF could be a novel treatment strategy to augment immunotherapy.
PMID: 29602801 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - March 30, 2018 Category: Cancer & Oncology Authors: Khanna S, Graef S, Mussai F, Thomas A, Wali N, Yenidunya BG, Yuan CM, Morrow B, Zhang J, Korangy F, Greten TF, Steinberg SM, Stetler-Stevenson M, Middleton G, De Santo C, Hassan R Tags: Clin Cancer Res Source Type: research