Cell culture-adaptive mutations in hepatitis C virus promote viral production by enhancing viral replication and release.

CONCLUSION: In this study, we generated infectious HCV particles with a robust titer of 1.61 × 106 FFUs/mL, and found that the viral replication and release levels could be enhanced by some of the adaptive mutations.
PMID: 29599605 [PubMed - in process]

Source: World Journal of Gastroenterology : WJG - March 28, 2018 Category: Gastroenterology Authors: Wang Q, Li Y, Liu SA, Xie W, Cheng J Tags: World J Gastroenterol Source Type: research