AI method lowers radiation dose, speeds scanning times

An artificial intelligence (AI) technique developed at Massachusetts General...Read more on AuntMinnie.comRelated Reading: AI advances MRI for prostate cancer patients Is artificial intelligence ethical in healthcare? Deep learning may produce sharp reductions in DBT dose AI can help distinguish lung nodules on CT scans Can AI help in the fight against gadolinium deposition?
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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Publication date: Available online 21 April 2019Source: Journal of Molecular StructureAuthor(s): Rafael G. Silveira, Beatriz N. Cunha, Juan C. Tenório, Deborah Victória Alves de Aguiar, Patricia da Cruz Souza, Boniek Gontijo Vaz, Javier Ellena, Alzir A. Batista, Felipe Terra MartinsAbstractAbiraterone acetate is a first choice prodrug to treat prostate cancer. New higher-solubility multicomponent crystal forms of the active compound abiraterone could substitute for the commonly used acetate prodrug. Here we prepare abiraterone hydrochloride monohydrate, which is the first multicomponent crystal form of this s...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Clinical nurse specialist Karen Walker explores the evolutionary journey of prostate cancer within hospitals and how the development of new technologies and treatments has contributed to improvements in outcomes Related items fromOnMedica Immune system boosters fight prostate cancer One-off PSA test doesn ’t save lives, finds largest study of its kind Radiotherapy offers hopes in advanced prostate cancer Prostate cancer diagnosis
Source: OnMedica Views - Category: Primary Care Source Type: news
ConclusionUsing structured data, we accurately classified patients’ cancer risk group, identified bone scan documentation with two NLP methods, and evaluated guideline adherence. Our pipeline can be used to provide concrete feedback to clinicians and guide treatment decisions.Graphical abstract
Source: Journal of Biomedical Informatics - Category: Information Technology Source Type: research
Publication date: Available online 16 April 2019Source: Seminars in Cancer BiologyAuthor(s): Samanta Salvi, Massimiliano Bonafè, Sara BravacciniAbstractThe possibility that a receptor for androgen is expressed in Breast Cancer (BC) is fascinating given that the tumor is predominantly estrogen-dependent.The androgen receptor (AR) is emerging as a new marker and a potential new therapeutic target in the treatment of BC patients. The recent availability of selective AR inhibitors (e.g. bicalutamide, enzalutamide, apalutamide) approved for the treatment of prostate cancer has opened up the possibility to use them in BC ...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
In conclusion, the present study demonstrated that USP9X is downregulated in prostate cancer and functions as an inhibitor of tumor cell invasion, possibly through the regulation of the ERK signaling pathway. PMID: 31002345 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
We examined the effects of pentacyclic triterpene pomolic acid (PA) on docetaxel‑resistant PC3 cells. Cell viability was evaluated using the MTT assay. Apoptosis was evaluated by cell cycle analysis using flow cytometry. The activity of multiple drug resistance (MDR) proteins was determined by the accumulation of specific substrates [mitoxantrone, rhodamine 123 and 5‑carboxyfluorescein diacetate (CFDA)]. The evaluation of epithelial to mesenchymal transition (EMT) proteins was conducted by immunocytochemical assays. It was demonstrated that PC3R cells presents multidrug resistance and EMT phenotype and express active P...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Zwacka Cell therapy is a promising new treatment option for cancer. In particular, mesenchymal stem cells (MSCs) have shown potential in delivering therapeutic genes in various tumour models and are now on the verge of being tested in the clinic. A number of therapeutic genes have been examined in this context, including the death ligand TRAIL. For cell therapy, it can be used in its natural form as a full-length and membrane-bound protein (FL-TRAIL) or as an engineered version commonly referred to as soluble TRAIL (sTRAIL). As to which is more therapeutically efficacious, contradicting results have been reported. We ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Publication date: Available online 19 April 2019Source: European UrologyAuthor(s): Michael Fraser
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 19 April 2019Source: International Journal of PharmaceuticsAuthor(s): Xiyu Ke, Haoyu Tang, Hai-Quan MaoAbstractNanoparticular system of a model small molecular drug curcumin (CUR) was prepared using a novel method, namely, flash nanocomplexation by hydrogen bonding interactions. The CUR-loaded nanoparticles (NPs) were fabricated by mixing CUR, tannic acid and polyvinyl alcohol (PVA) in aqueous solutions under turbulent condition through a three-inlet confined impinging jet (CIJ) device. Compared to bulk mixing, FNC has the advantage of scalability, reproducibility and without causing the ...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 18 April 2019Source: Journal of Sport and Health ScienceAuthor(s): Xin Luan, Xiangyang Tian, Haixin Zhang, Rui Huang, Na Li, Peijie Chen, Ru WangAbstractA growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy. Because each sport has its own set of characteristics and physiological complications that tend to appear during exercise training, the effects and underlying mechanisms of exercise remain unclear. Thus, the first step in probing exercise effects on different diseases is the s...
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
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