Clozapine Discontinuation and Malignant Catatonia: A Case Report

Malignant catatonia is a severe, potentially life-threatening variant of catatonia marked by hyperthermia, autonomic instability and rigidity. The condition is often viewed as being on the same spectrum as neuroleptic malignant syndrome. Causes of malignant catatonia include psychiatric illness, antipsychotic medications, illicit drug use, and intoxications with other agents. Malignant catatonia has also been reported in the setting of discontinuation of antipsychotic medications, specifically clozapine.
Source: Psychosomatics - Category: Psychiatry & Psychology Authors: Source Type: research