HBV cccDNA-selective droplet digital PCR: A sensitive and noninvasive method for HCC diagnosis?

Chronic hepatitis B virus (HBV) infection (CHB) continues to be a major health burden with approximately 240 million CHB patients worldwide and 680,000 CHB-related deaths yearly (1). Although HBV vaccination is available, unsafe contact and immunosuppression may trigger CHB-related complications. CHB can cause hepatocellular damage. Also, CHB is strongly associated with the development of liver cirrhosis and the onset of autonomous neoplastic clones of hepatocytes that eventually become carcinomas (2,3).
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Tags: Commentary Source Type: research