Kallikrein-related peptidase 6 can cleave human-muscle-type 6-phosphofructo-1-kinase into highly active shorter fragments

Conclusion KLK6 may be the key protease involved in the modification of PFK-M and trigger deregulated glycolytic flux in cancer cells.

Source: Biochimica et Biophysica Acta (BBA) Proteins and Proteomics - March 19, 2018 Category: Biochemistry Source Type: research