Melancholy, anhedonia, apathy: the search for separable behaviors and neural circuits in depression.

Melancholy, anhedonia, apathy: the search for separable behaviors and neural circuits in depression.
Curr Opin Neurobiol. 2018 Mar 09;49:192-200
Authors: Post RJ, Warden MR
Abstract
Major depressive disorder can manifest as different combinations of symptoms, ranging from a profound and incapacitating sadness, to a loss of interest in daily life, to an inability to engage in effortful, goal-directed behavior. Recent research has focused on defining the neural circuits that mediate separable features of depression in patients and preclinical animal models, and connections between frontal cortex and brainstem neuromodulators have emerged as candidate targets. The development of methods permitting recording and manipulation of neural circuits defined by connectivity has enabled the investigation of prefrontal-neuromodulatory circuit dynamics in animal models of depression with exquisite precision, a systems-level approach that has brought new insights by integrating these fields of depression research.
PMID: 29529482 [PubMed - as supplied by publisher]

Source: Current Opinion in Neurobiology - March 9, 2018 Category: Neurology Authors: Post RJ, Warden MR Tags: Curr Opin Neurobiol Source Type: research