Long-term Effects of Fecal Transplant in Recurrent C. Diff Long-term Effects of Fecal Transplant in Recurrent C. Diff

Treatment of recurrent C. difficile infection with fecal microbiota transplantation has been shown to be safe in the short term, but might there be long-term adverse effects?Alimentary Pharmacology &Therapeutics
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

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Condition:   Clostridium Difficile Infection Intervention:   Drug: Lyophilized Fecal Microbiota Transplantation Sponsor:   Vancouver Island Health Authority Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We report results in 10 adult patients colonized with multidrug-resistant bacteria, undergoing fecal microbiota transplantation before (n=4) or after (n=6) allogeneic hematopoietic stem cell transplantation for hematologic malignancies. Stools were obtained from healthy related or unrelated donors. Fecal material was delivered either by enema or via nasogastric tube. Patients were colonized or had infections from either carbapenemase-producing bacteria (n=8) or vancomycin-resistant enterococci (n=2). The median age at fecal microbiota transplantation was 48 (range 16-64) years. Three patients needed a second transplant fro...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
Fecal microbiota transplantation (FMT) has proved its efficacy for treating recurrent Clostridium difficile infection, but an effective FMT protocol is still yet to be found for treating ulcerative colitis (UC). We previously demonstrated that fresh fecal-microbiota transplantation (FMT) following triple-antibiotic therapy [amoxicillin, fosfomycin, and metronidazole (AFM); A-FMT] induced dramatic changes in the phylum Bacteroidetes, which constitutes a critical factor correlated with clinical responses.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Microbiome Source Type: research
Fecal Microbiota Transplantation (FMT) is effective for the treatment of recurrent Clostridium difficile infection, but its efficacy for ulcerative colitis (UC) remains controversial. Ishikawa, et  al reported that combination therapy with FMT and antibiotic pretreatment were effective in patients with UC. In addition, in most of the previous reports, FMT solution is usually prepared under aerobic conditions, and anaerobic bacteria might be decreased during this procedure. To improve the out come of FMT for UC, we performed the repeated FMT using fecal solution prepared under the anaerobic condition following the antibiotic pretreatment.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Microbial-Based Therapy Source Type: research
AbstractClostridium difficile infections (CDI) dramatically increased during the last decade and cause a major public health problem. Current treatments are limited by the high disease recurrence rate, severity of clinical forms, disruption of the gut microbiota, and colonization by vancomycin-resistant enterococci (VRE). In this review, we resumed current treatment options from official recommendation to promising alternatives available in the management of adult CDI, with regard to severity and recurring or non-recurring character of the infection. Vancomycin remains the first-line antibiotic in the management of mild to...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
There are significant risks associated with central line associated blood stream infections (CLABSI), catheter associated urinary tract infections (CAUTI), Clostridium difficile (C. diff) and falls in the transplant and cellular therapy population. Our hospital has a nursing-led shared governance program. Each nurse is involved in one of four unit-based councils that focus on Evidence-based Practice, Development, Quality, and Research. Quality Council focuses on monitoring initiatives implemented to improve patient care of the transplant and cellular therapy (BMT) patient population.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 665 Source Type: research
This article reviews the new guidelines and strategies for diagnosis and infection control.
Source: Journal of the American Academy of Physician Assistants - Category: Primary Care Tags: Special Topics in Infectious Diseases Source Type: research
Authors: Dinleyici M, Vandenplas Y Abstract Clostridium difficile (C. diff) is the most common causative agent of antibiotic-associated diarrhea and colitis. This spore-forming, obligate anaerobic, gram-positive bacillus is becoming responsible for an increasing number of infections worldwide, both in community and in hospital settings, whose severity can vary widely from an asymptomatic infection to a lethal disease. While discontinuation of antimicrobial agents and antibiotic treatment of the infection remain the cornerstone of therapy, the use of probiotics, especially Saccharomyces boulardii, and more recently ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Xiao J, Peng Z, Liao Y, Sun H, Chen W, Chen X, Wei Z, Yang C, Nüssler AK, Liu J, Yang W Abstract Organ transplantation is often the only effective treatment for patients with end-stage diseases, such as heart, liver, kidney and small bowel failure and is carried out frequently worldwide. Still the post-transplantation complications remain health- and life-threatening outcome that needed to be resolved. With the rapid development of molecular technologies in recent years, more and more researchers realize that the gut microbiota may play a critical role in human diseases. The intestinal microbiome has ...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
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