Long-term Effects of Fecal Transplant in Recurrent C. Diff Long-term Effects of Fecal Transplant in Recurrent C. Diff
Treatment of recurrent C. difficile infection with fecal microbiota transplantation has been shown to be safe in the short term, but might there be long-term adverse effects?Alimentary Pharmacology &Therapeutics
Amoe Baktash, Elisabeth M. Terveer, Romy D. Zwittink, Bastian V. H. Hornung, Jeroen Corver, Ed J. Kuijper, Wiep Klaas Smits
Conditions: Clostridial Infection; Dysbacteriosis; Probiotic Therapy Interventions: Procedure: Fecal Microbiota Transplantation (FMT); Drug: Saline Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting
Altruism, and a little financial incentive, can be motivating factors.
Conclusion Low-quality to moderate-quality evidence showed that encapsulated FMT is safe and cost-effective for the treatment and prevention of recurrent CDI. Its efficacy is not inferior to FMT performed through the nonoral route. Randomized-controlled trials are necessary to compare its efficacy with oral antimicrobial drugs and also to evaluate the potential adverse effects associated with the treatment.
Abstract Increasing evidence suggests that asymptomatic carriers are an important source of healthcare-associated Clostridium difficile infection. However, it is not known which test for the detection of C. difficile colonization is most sensitive in patients with haematological malignancies. We performed a prospective cohort study of 101 patients with haematological malignancies who had been admitted to the hospital for scheduled chemotherapy or haematopoietic cell transplantation. Each patient provided a formed stool sample. We compared the performance of five different commercially available assays, using toxig...
In a small study, doctors used so-called fecal transplants to treat a serious gut infection in patients. The transplants, from healthy donors, were as effective as antibiotics.
How can more poop actually help with severe diarrhea? Well, when the diarrhea is caused by the antibiotic-resistant bacteria Clostridium difficile, a poop transplant may help get to the bottom of the problem.
Instead of waiting until antibiotics have failed before trying fecal transplants, researchers tried giving the fecal bacteria first.