Cholesterol Variability and Mortality, MI, and Stroke Risk Cholesterol Variability and Mortality, MI, and Stroke Risk

Is high visit-to-visit variability in lipid levels an independent predictor of adverse cardiometabolic events?European Heart Journal
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

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In this study, we assessed both genetic and nongenetic factors that influence drug responses and stratified patients into groups based on differential drug effect and sensitivity. Our methodology of investigating genetic factors and nongenetic factors is applicable to studying differential effects of other drugs, such as statins, and provides an approach to the development of personalized medicine.
Source: BMC Proceedings - Category: Biomedical Science Source Type: research
In this study, we conducted RNA profiling in THP-1 derived macrophages treated with LPC and uncovered a relationship between LPC and the cholesterol biosynthesis pathway. Principal component analysis (PCA) of RNA profiling showed that untreated THP-1 cells and those treated with 10, 20, or 40 µM LPC were distinctly distributed. Functional annotation revealed that LPC affected the expression of genes involved in cytokine–cytokine receptor interaction, TNF signaling, and MAPK signaling. Interestingly, LPC also altered the expression of 11 genes involved in cholesterol synthesis such as those in terpenoid backbone...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
In this report, we present a detailed analysis of how the patterns of cardiovascular diseases and major risk factors have changed across the states of India between 1990 and 2016.MethodsWe analysed the prevalence and disability-adjusted life-years (DALYs) due to cardiovascular diseases and the major component causes in the states of India from 1990 to 2016, using all accessible data sources as part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2016. We placed states into four groups based on epidemiological transition level (ETL), defined using the ratio of DALYs from communicable diseases to those fro...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
CONCLUSIONS: Patients with a history of mild ischemic stroke had low MVPA and high VFL values, which together may be a risk factor for RIS. PMID: 30207894 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - Category: Neurology Authors: Tags: Top Stroke Rehabil Source Type: research
For years, experts have recommended low-fat dairy products over the full-fat versions, which are higher in calories and contain more saturated fat. Recent research, however, indicates that full-fat dairy may actually be healthier than its reputation suggests, and that people who eat full-fat dairy are not more likely to develop cardiovascular disease and type 2 diabetes than people who consume low-fat dairy. They may even be less likely to gain weight. Now, new research published Tuesday in The Lancet, adds to that body of evidence. The research suggests that eating dairy products of all kinds is associated with a lower ri...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Diet/Nutrition healthytime Source Type: news
Evidence does not support the widespread use of statins in healthy older people to prevent heart disease and stroke, according to the authors of a new Spanish study.
Source: Nursing Times - Category: Nursing Source Type: news
Publication date: Available online 5 September 2018Source: Trends in Food Science &TechnologyAuthor(s): Teng Wang, Changhu Xue, Tiantian Zhang, Yuming WangABSTRACTHyperlipidemia with the characteristic of excessive blood lipid level is a risk factor for stroke, coronary heart disease, myocardial infarction, hypertension, impaired glucose tolerance, diabetes, sudden death, and so on. Therefore, we should pay more attention to the dangers of hyperlipidemia and look for natural lipid-lowering ingredients to prevent and relieve hyperlipidemia. In recent years, various studies have shown that active ingredients from marine ...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
Abstract BACKGROUND: Diabetes mellitus increases the risk of ischaemic stroke in the general population but its impact on early outcome after the carotid endarterectomy (CEA) is controversial with conflicting results. PATIENTS AND METHODS: This prospective study includes 902 consecutive CEAs. Patients were divided into non-diabetic and diabetic groups and subsequently analysed. Early outcomes in terms of 30-day stroke and death rates were then analysed and compared. RESULTS: There were 606 non-diabetic patients. Among 296 diabetic patients, 83 were insulin-dependent. The cumulative TIA/stroke rate was st...
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - Category: Surgery Authors: Tags: Vasa Source Type: research
Heart problems that were “largely preventable” killed around 415,000 Americans in 2016, new data from the Centers for Disease Control and Prevention (CDC) says, highlighting the importance of proactive interventions. Under its new Million Hearts campaign, which aims to prevent a million heart attacks and strokes by 2022, the CDC looked at 2016 data and identified approximately 2.2 million hospitalizations and 415,000 deaths caused by heart attacks, strokes, heart failure and related conditions that likely could have been avoided. The total number of deaths related to heart issues is even higher — in 2015,...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Heart Disease onetime Source Type: news
THURSDAY, Sept. 6, 2018 -- There is no evidence to support the widespread use of cholesterol-lowering statin drugs to prevent heart disease and stroke in old and very old people, Spanish researchers say. For the new study, the investigators analyzed...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
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