How infertility treatment has left sperm science behind

LONDON, (Reuters) – - They can make test-tube babies, grow human eggs in a lab and reproduce mice from frozen testicle tissue, but when it comes to knowing how a man's sperm can swim to, find and fertilize an egg, scientists are still floundering.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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This study was performed from 2015 to 2017 in the Division of Reproductive Endocrinology and Infertility at Northwestern University. We included patients who became pregnant after IVF-PGS who were seen by the Division of Reproductive Genetics and non-PGS control group.ResultsSixty-eight patients were included. A total of 50 patients (73.5%) opted for non-invasive prenatal screening; 5 (7.4%) had invasive testing (4 had chorionic villus sampling and 1 had amniocentesis). A total of 13 patients (19%) declined further genetic testing. When comparing demographic data, the mean age was significantly higher in the group of patie...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Publication date: Available online 15 August 2018Source: SteroidsAuthor(s): Julius Fink, Masahito Matsumoto, Yoshifumi TamuraAbstractSedentary lifestyle and over-nutrition are the main causes of obesity and type 2 diabetes (T2D). However, the same causes are major triggers of hypogonadism. Many T2D patients show low testosterone levels while hypogonadal men seem to be prone to become diabetic. Testosterone plays a major role in the regulation of muscle mass, adipose tissue, inflammation and insulin sensitivity and is therefore indirectly regulating several metabolic pathways, while T2D is commonly triggered by insulin resi...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 15 August 2018Source: Journal of Chemical NeuroanatomyAuthor(s): Cornelia Voigt, Nigel BennettAbstractThe eusocial Damaraland mole-rat (Fukomys damarensis) represents an extreme example of reproductive skew, in that reproduction is completely blocked in female subordinate group members. It is thought that in these animals normal GnRH secretion from the hypothalamus is disrupted. Prolactin, a peptide hormone secreted from the anterior pituitary gland, has been implicated in a wide variety of functions. Well documented in rodents is its role in mediating lactational infertility. Elevated ci...
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research
Authors: Barut MU, Çoksüer H, Sak S, Bozkurt M, Ağaçayak E, Hamurcu U, Kurban D, Eserdağ S Abstract BACKGROUND Hypogonadotropic hypogonadism (HH), or secondary hypogonadism, results from reduced secretion of gonadotropins, including follicle-stimulating hormone (FSH) and luteinizing hormone (LH), by the pituitary gland, resulting in lack of production of sex steroids. The aim of this study was to evaluate self-reported sexual function in sexually active women with and without HH using two evaluation methods, the Female Sexual Function Index (FSFI) and the Beck Depression Inventory (BDI). MATERI...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
ConclusionCompared to non-PCOS patients, PCOS patients had greater postoperative ΔBMI and %EWL at 1 year. The majority of patients becoming pregnant after VSG were previously nulliparous. This study shows that VSG is effective for weight loss in PCOS patients with obesity and may positively augment effect fertility rates.
Source: Obesity Surgery - Category: Surgery Source Type: research
Uterine myomas are benign uterine tumors that originate from smooth muscle cells of the myometrium. This common complication can be associated with irreversible complications, including infertility and malignancy. Better understanding of the genetic characteristics of myoma may effect on treatment. Epidermal growth factor receptor gene (EGFR) is one of the most important genes that has the major role in the pathogenesis of myoma, cell growth, differentiation, proliferation and mutagenesis. The aim of this study was to investigate EGFR common gene mutations in Iranian women with uterine fibroids.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Full length article Source Type: research
Dear science, Today my sons, Oliver and Victor, are 15 years old. It is not a miracle; it is thanks to you. Unable to get pregnant I needed infertility therapy. If you had not isolated the hormones, developed tests, and then designed medications for ovarian stimulation and to trigger ovulation I would never have become pregnant. If ultrasound had not been developed I would not have known I was pregnant with triplets and then what eventually happened next would likely have been even more of a catastrophe. It is sometimes hard to see how these kinds of things helped, but I have not forgotten. I know there is an orchestra inv...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Physician OB/GYN Pediatrics Source Type: blogs
The actress has spoken candidly about her struggles with infertility for years, and revealed in a new interview that she was diagnosed with a certain type of endometriosis known as adenomyosis.
Source: ABC News: Health - Category: Consumer Health News Tags: GMA Source Type: news
The actress opened up about her struggles with infertility in her memoir.
Source: ABC News: Health - Category: Consumer Health News Tags: GMA Source Type: news
AbstractAlthough assisted reproduction techniques involve the use of semen samples, there is little scientific methodology applied when selecting sperm. To select the most appropriate spermatozoa, first we need to define the optimal molecular characteristics. Sperm lipids may contribute to sperm function, thus our aim was to compare the lipidic profiles of sperm samples used in intracytoplasmic sperm injection cycles that ultimately led to a pregnancy with those that did not.Spermatozoa from infertile patients after intracytoplasmic sperm injection (group non-pregnant,n = 16; vs. group pregnant,n =&thi...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
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