Prevention of diabetic nephropathy by compound 21, selective agonist of the angiotensin type 2 receptors, in zucker diabetic fatty rats.

PREVENTION OF DIABETIC NEPHROPATHY BY COMPOUND 21, SELECTIVE AGONIST OF THE ANGIOTENSIN TYPE 2 RECEPTORS, IN ZUCKER DIABETIC FATTY RATS. Am J Physiol Renal Physiol. 2014 Sep 3; Authors: Castoldi G, di Gioia CR, Bombardi C, Maestroni S, Carletti R, Steckelings UM, Dahlöf B, Unger T, Zerbini G, Stella A Abstract Aim of the study was to evaluate the effect of compound 21 (C21), selective AT2 receptor agonist, in diabetic nephropathy and the potential additive effect of C21, when associated to losartan treatment, on the development of albuminuria and renal fibrosis in Zucker diabetic fatty (ZDF) rats. The experiments lasted 15 weeks (from 5 to 20 weeks of age) and were performed in 40 ZDF rats and 12 control Lean rats. ZDF rats were divided in 4 groups: 1) Nine rats were treated with losartan; 2) Ten rats were treated with C21; 3) Nine rats were treated with losartan plus C21; 4) twelve rats were maintained without any treatment. ZDF rats showed an increase in blood glucose level, albuminuria, renal fibrosis, macrophage infiltration and TNF- expression and a reduction of glomerular nephrin expression compared to control Lean rats. C21 treatment reduced renal glomerular, tubulointerstitial and perivascular fibrosis, and macrophage infiltration and TNF- expression in ZDF rats. C21 treatment caused a decrease in albuminuria in ZDF rats up to 11 weeks of age. Losartan decreased macrophage infiltration, TNF- expression and renal glomerular a...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research