Oral pemphigus.

Oral pemphigus. G Ital Dermatol Venereol. 2018 Mar 06;: Authors: Giannetti L, Generali L, Bertoldi C Abstract Involvement of the oral mucosa in patients affected by Pemphigus Vulgaris (PV), Paraneoplastic, IgA Pemphigus and in some cases of Iatrogenic Pemphigus is common, and precede skin lesions in the majority of cases. Intraepidermal bullae are caused by acantholysis, induced by IgG autoantibodies directed against the desmosomes and the domain of numerous keratinocytes self-antigens desmogleins (namely cadherins), thus supporting the autoimmune nature of the disease. Apoptosis may contribute to the acantholysis.The oral mucosal lesions tend more often to be refractory to treatment than skin lesions, and have been associated with disease duration, disease location and possibly the presence of HSV DNA in the oral cavity. Recent publications have stressed the positive role of Rituximab in early disease treatment. PMID: 29512980 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29512980?dopt=Abstract

Source: Giornale Italiano di Dermatologia e Venereologia - March 8, 2018 Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research