Synthesis and DFT study on Hantzsch reaction to produce asymmetrical compounds of 1,4-dihydropyridine derivatives for P-glycoprotein inhibition as anticancer agent.

CONCLUSION: In this study, selected reactants by DFT calculation have increased yield of reaction from 36% to 74% without any catalyst. Diversity of products is noticeable topic. Racemic asymmetric compounds with R and S enantiomers have potential for enantiomeric separation. Each of these enantiomers could have different physiological effect. PMID: 29468983 [PubMed - as supplied by publisher]
Source: Recent Patents on Anti-Cancer Drug Discovery - Category: Cancer & Oncology Tags: Recent Pat Anticancer Drug Discov Source Type: research