Pretransplant Gut Colonization with Intrinsically Vancomycin-Resistant Enterococci (E. gallinarum and E. casseliflavus) and Outcomes of Allogeneic Hematopoietic Cell Transplantation

Gut colonization with vancomycin-resistant enterococci (VRE) —Enterococcus faecium and Enterococcus faecalis—is common. Approximately 15% to 40% of patients are VRE colonized before allogeneic hematopoietic cell transplantation (allo-HCT) and an additional ~10% become colonized within the first 100 days post-HCT [1-3]. We and others have shown that VRE co lonization is associated with>3-fold increased risk of post-HCT VRE bloodstream infection [1,2,4] with an attributable mortality rate of ~10% [2,3,5,6].

Source: Biology of Blood and Marrow Transplantation - February 3, 2018 Category: Hematology Authors: Armin Rashidi, Maryam Ebadi, Robin R. Shields-Cutler, Todd E. DeFor, Gabriel A. Al-Ghalith, Patricia Ferrieri, Jo-Anne H. Young, Gary M. Dunny, Dan Knights, Daniel J. Weisdorf Source Type: research