Cohort-Controlled Comparison of Umbilical Cord Blood Transplantation Using Carlecortemcel-L, a Single Progenitor-Enriched Cord Blood, to Double Cord Blood Unit Transplantation

• Expanding a portion of a UCB unit in cytokines with tetraethylenepentamine led to a median 77 fold expansion of CD34+ cells• Compared to a contemporaneous double UCB cohort, transplantation of expanded and remaining unexpanded cells led to a lower 100 day mortality• Faster neutrophil and pla telet engraftment was also seen also for the group transplanted with the expanded cells

Source: Biology of Blood and Marrow Transplantation - February 22, 2018 Category: Hematology Authors: Patrick J. Stiff, Pau Montesinos, Tony Peled, Efrat Landau, Noga Rosenheimer Goudsmid, Julie Mandel, Nira Hasson, Esti Olesinski, Ela Glukhman, David A. Snyder, Einat Galamidi Cohen, Orna Srur Kidron, Dalia Bracha, Dorit Harati, Keren Ben-Abu, Etty Freind Source Type: research